Inhibition of lipid peroxidation by N-Acetylserotonin and its role in retinal physiology

被引：42

作者：

Longoni, B ^{[1
]}

Pryor, WA ^{[1
]}

Marchiafava, P ^{[1
]}

机构：

[1] LOUISIANA STATE UNIV,INST BIODYNAM,BATON ROUGE,LA 70803

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 233卷 / 03期

关键词：

D O I：

10.1006/bbrc.1997.6563

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

N-Acetylserotonin (NAS) inhibits the peroxidation of linoleic acid induced by a water-soluble initiator, 2,2'-azobis(2-amidinopropane) (ABAP), Lipid peroxidation was detected by the formation of conjugated dienes, monitored spectrophotometrically at 236 nm, N-Acetylserotonin, at concentrations ranging from 200 nM to 20 mu M, reduced the rate of ABAP-initiated lipid peroxidation in a concentration-dependent manner. The results of NAS-inhibited lipid peroxidation are compared to the antioxidant activities of melatonin, vitamin E, and a water-soluble vitamin E analog, Trolox. Pt is suggested that NAS acts as a physiological antioxidant in retinal photoreceptor cells. (C) 1997 Academic Press.

引用

页码：778 / 780

页数：3

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