Body mass index and cardiovascular disease in the Asia-Pacific Region: an overview of 33 cohorts involving 310 000 participants

被引：258

作者：

Mhurchu, CN ^{[1
]}

Rodgers, A ^{[1
]}

Pan, WH ^{[1
]}

Gu, DF ^{[1
]}

Woodward, M ^{[1
]}

Parag, V ^{[1
]}

Lin, R ^{[1
]}

Bennett, DA ^{[1
]}

Vander Hoorn, S ^{[1
]}

Woodward, M ^{[1
]}

Barzi, F ^{[1
]}

MacMahon, S ^{[1
]}

Bennett, DA ^{[1
]}

Gu, DF ^{[1
]}

Lam, TH ^{[1
]}

Lawes, C ^{[1
]}

Pan, WH ^{[1
]}

Rodgers, A ^{[1
]}

Suh, I ^{[1
]}

Ueshima, H ^{[1
]}

Woodward, M ^{[1
]}

Okayama, A ^{[1
]}

Ueshima, H ^{[1
]}

Maegawa, H ^{[1
]}

Aoki, N ^{[1
]}

Nakamura, M ^{[1
]}

Kubo, N ^{[1
]}

Yamada, T ^{[1
]}

Wu, ZS ^{[1
]}

Yao, CH ^{[1
]}

Wu, ZS ^{[1
]}

Liu, LS ^{[1
]}

Xie, JX ^{[1
]}

Knuiman, MW ^{[1
]}

Christensen, H ^{[1
]}

Wu, XG ^{[1
]}

Zhou, J ^{[1
]}

Yu, XH ^{[1
]}

Tamakoshi, A ^{[1
]}

Wu, ZL ^{[1
]}

Chen, LQ ^{[1
]}

Shan, GL ^{[1
]}

Gu, DF ^{[1
]}

Duan, XF ^{[1
]}

MacMahon, S ^{[1
]}

Norton, R ^{[1
]}

Whitlock, G ^{[1
]}

Jackson, R ^{[1
]}

Fujishima, M ^{[1
]}

Kiyohara, Y ^{[1
]}

机构：

[1] Univ Auckland, Asia Pacific Cohort Studies Collaborat, Clin Trials Res Unit, Fac Med & Hlth Sci, Auckland 1, New Zealand

来源：

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | 2004年 / 33卷 / 04期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

obesity; body mass index; cardiovascular disease; overview; cohort study; Asia;

D O I：

10.1093/ije/dyh163

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background Few prospective data from the Asia-Pacific region are available relating body mass index (BMI) to the risks of stroke and ischaemic heart disease (IHD). Our objective was to assess the age-, sex-, and region-specific associations of BMI with cardiovascular disease using individual participant data from prospective studies in the Asia-Pacific region. Methods Studies were identified from literature searches, proceedings of meetings, and personal communication. All studies had at least 5000 person-years of follow-up. Hazard ratios were calculated from Cox models, stratified by sex and cohort, and adjusted for age at risk and smoking. The first 3 years of follow-up were excluded in order to reduce confounding due to disease at baseline. Results A total of 33 cohort studies, including 310 283 participants, contributed 2 148 354 person-years of follow-up, during which 3332 stroke and 2073 IHD events were observed. There were continuous positive associations between baseline BMI and the risks of ischaemic stroke, haemorrhagic stroke, and IHD, with each 2 kg/m(2) lower BMI associated a 12% (95% CI: 9, 15%) lower risk of ischaemic stroke, 8% (95% CI: 4, 12%) lower risk in haemorrhagic stroke, and 11% (95% CI: 9, 13%) lower risk of IHD. The strengths of all associations were strongly age dependent, and there was no significant difference between Asian and Australasian cohorts. Conclusions This overview provides the most reliable estimates to date of the associations between BMI and cardiovascular disease in the Asia-Pacific region, and the first direct comparisons within the region. Continuous relationships of approximately equal strength are evident in both Asian and Australasian populations. These results indicate considerable potential for cardiovascular disease reduction with population-wide lowering of BMI.

引用

页码：751 / 758

页数：8

共 46 条

[1]

[Anonymous], TACKL OB ENGL

[2]

[Anonymous], 1998, OB PREV MAN GLOB EP

[3]

[Anonymous], 2002, RED RISKS PROM HLTH

[4]

*AS PAC COH STUD C, 1999, CVD PREVENTION, V0002