Maternal inheritance of atopy at the Fc epsilon RI beta locus in Japanese sibs

被引：10

作者：

Mao, XQ

Shirakawa, T

Sasaki, S

Enomoto, T

Morimoto, K

Hopkin, JM

机构：

[1] OSAKA UNIV,SCH MED,DEPT HYG & PREVENT MED,SUITA,OSAKA 565,JAPAN

[2] CHURCHILL HOSP,OSLER CHEST UNIT,OXFORD OX3 7LJ,ENGLAND

[3] OSAKA MED COLL,DEPT PEDIAT,TAKATSUKI,OSAKA 569,JAPAN

[4] JAPAN RED CROSS SOC,WAKAYAMA MED CTR,DEPT ORL,WAKAYAMA,JAPAN

来源：

HUMAN HEREDITY | 1997年 / 47卷 / 03期

关键词：

atopy; Fc epsilon RI beta; microsatellite repeats; maternal inheritance; affected sib-pair analysis;

D O I：

10.1159/000154409

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Twenty-four Japanese atopic sibs with asthma and/or rhinitis were tested for polymorphic microsatellite repeats of Fc epsilon RI beta on chromosome 11q13. Significantly increased sharing of maternal alleles was found (chi(2) = 5.86, p < 0.025) while no significant sharing was found for paternal alleles. These findings confirm maternal inheritance of atopy at this locus in a non-Caucasian population.

引用

页码：178 / 180

页数：3

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