Diabetes - Insulin resistance and obesity

被引：34

作者：

Schwartz, MW ^{[1
]}

Kahn, SE

机构：

[1] Univ Washington, Harborview Med Ctr, Dept Med, Seattle, WA 98108 USA

[2] VA Puget Sound Hlth Care Syst, Seattle, WA 98108 USA

来源：

NATURE | 1999年 / 402卷 / 6764期

关键词：

D O I：

10.1038/47209

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Type 2 diabetes arises when resistance to the glucose-lowering effects of insulin combines with impaired insulin secretion to raise the levels of glucose in the blood. Studies into the molecular basis of insulin resistance have focused on the peroxisome proliferator-activated receptor gamma (PPAR-gamma). Three patients with type 2 diabetes have been identified with loss-of-function mutations in thePPAR-gammagene, indicating that this protein is required for normal insulin sensitivity.

引用

页码：860 / 861

页数：2

共 10 条

[1] PPARγ, the ultimate thrifty gene [J].

Auwerx, J .

DIABETOLOGIA, 1999, 42 (09) :1033-1049

[2] Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension [J].

Barroso, I ;

Gurnell, M ;

Crowley, VEF ;

Agostini, M ;

Schwabe, JW ;

Soos, MA ;

Maslen, GL ;

Williams, TDM ;

Lewis, H ;

Schafer, AJ ;

Chatterjee, VKK ;

O'Rahilly, S .

NATURE, 1999, 402 (6764) :880-883

[3] A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity [J].

Deeb, SS ;

Fajas, L ;

Nemoto, M ;

Pihlajamäki, J ;

Mykkänen, L ;

Kuusisto, J ;

Laakso, M ;

Fujimoto, W ;

Auwerx, J .

NATURE GENETICS, 1998, 20 (03) :284-287

[4] Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPAR gamma [J].

Hu, ED ;

Kim, JB ;

Sarraf, P ;

Spiegelman, BM .

SCIENCE, 1996, 274 (5295) :2100-2103

[5] QUANTIFICATION OF THE RELATIONSHIP BETWEEN INSULIN SENSITIVITY AND BETA-CELL FUNCTION IN HUMAN-SUBJECTS - EVIDENCE FOR A HYPERBOLIC FUNCTION [J].

KAHN, SE ;

PRIGEON, RL ;

MCCULLOCH, DK ;

BOYKO, EJ ;

BERGMAN, RN ;

SCHWARTZ, MW ;

NEIFING, JL ;

WARD, WK ;

BEARD, JC ;

PALMER, JP ;

PORTE, D .

DIABETES, 1993, 42 (11) :1663-1672

[6] Obesity associated with a mutation in a genetic regulator of adipocyte differentiation [J].

Ristow, M ;

Müller-Wieland, D ;

Pfeiffer, A ;

Krone, W ;

Kahn, CR .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (14) :953-959

[7] Loss-of-function mutations in PPARγ associated with human colon cancer [J].

Sarraf, P ;

Mueller, E ;

Smith, WM ;

Wright, HM ;

Kum, JB ;

Aaltonen, LA ;

de la Chapelle, A ;

Spiegelman, BM ;

Eng, C .

MOLECULAR CELL, 1999, 3 (06) :799-804

[8] Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells:: A new possible role of PPARγ on vascular endothelial function [J].

Satoh, H ;

Tsukamoto, K ;

Hashimoto, Y ;

Hashimoto, N ;

Togo, M ;

Hara, M ;

Maekawa, H ;

Isoo, N ;

Kimura, S ;

Watanabe, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 254 (03) :757-763

[9] PPARγ in monocytes:: Less pain, any gain? [J].

Spiegelman, BM .

CELL, 1998, 93 (02) :153-155

[10] Two polymorphisms in the peroxisome proliferator-activated receptor-γ gene are associated with severe overweight among obese women [J].

Valve, R ;

Sivenius, K ;

Miettinen, R ;

Pihlajamäki, J ;

Rissanen, A ;

Deeb, SS ;

Auwerx, J ;

Uusitupa, M ;

Laakso, M .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (10) :3708-3712

← 1 →