Environmental prognostics: Is the current use of biomarkers appropriate for environmental risk evaluation?

被引：99

作者：

Allen, JI ^{[1
]}

Moore, MN ^{[1
]}

机构：

[1] Plymouth Marine Lab, Plymouth PL1 3DH, Devon, England

来源：

MARINE ENVIRONMENTAL RESEARCH | 2004年 / 58卷 / 2-5期

关键词：

systems biology; biomarkers; numerical models; statistics; health status indices;

D O I：

10.1016/j.marenvres.2004.03.119

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Environmental Prognostics is proposed as an integrated explanatory framework for adverse changes in whole systems, from cells to animals to ecosystems. The aim is to develop such frameworks for the evaluation of "health of the environment" and prediction of consequences resulting from future environmental events based on integrating the reactions of biomarkers for cellular and physiological processes, through conceptual, statistical and computational modelling. These are urgently needed to synthesise complex information on environmental chemistry and injurious effects of pollutants into predicted harmful impact on health of sentinel animals. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：227 / 232

页数：6

共 12 条

[1] BACKGROUND AND RATIONALE TO A PRACTICAL WORKSHOP ON BIOLOGICAL EFFECTS OF POLLUTANTS [J].