Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease

被引：29

作者：

Adighibe, Omanma ^{[1
]}

Arepalli, Sampath ^{[1
]}

Duckworth, Jaime ^{[1
]}

Hardy, John ^{[1
]}

Wavrant-De Vrieze, Fabienne ^{[1
]}

机构：

[1] NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA

来源：

NEUROBIOLOGY OF AGING | 2006年 / 27卷 / 10期

关键词：

Alzheimer's disease; genetics; cholesterol; LXR gene;

D O I：

10.1016/j.neurobiolaging.2005.08.010

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We have initiated a systematic analysis of the role of cholesterol metabolizing genes as risk factors for Alzheimer's disease pathogenesis. As part of this analysis, we have assessed the NR1H2 gene on chromosome 19 and report here a modest association with the locus in sibpairs with late onset disease. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1431 / 1434

页数：4

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