A cell biological perspective on Alzheimer's disease

被引：189

作者：

Annaert, W

De Strooper, B

机构：

[1] Flanders Interuniv Inst Biotechnol VIB, Neuronal Cell Biol Lab, B-3000 Louvain, Belgium

[2] Catholic Univ Louvain, Ctr Human Genet, B-3000 Louvain, Belgium

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2002年 / 18卷

关键词：

regulated intramembrane proteolysis; presenilin; APP; secretase; nicastrin;

D O I：

10.1146/annurev.cellbio.18.020402.142302

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The amyloid precursor protein and the proteases cleaving this protein are important players in the pathogenesis of Alzheimer's disease via the generation of the amyloid peptide. Physiologically, the amyloid precursor protein is implied in axonal vesicular trafficking and the proteases are implicated in developmentally important signaling pathways, most significantly those involving regulated intramembrane proteolysis or RIP. We discuss the cell biology behind the amyloid and tangle hypothesis for Alzheimer's disease, drawing on the many links to the fields of cell biology and developmental biology that have been established in the recent years.

引用

收藏

页码：25 / 51

页数：31

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