NADPH Oxidase 1 and Its Derived Reactive Oxygen Species Mediated Tissue Injury and Repair

被引：57

作者：

Fu, Xiu-Jun ^{[1
]}

Peng, Ying-Bo ^{[1
]}

Hu, Yi-Ping ^{[1
,2
]}

Shi, You-Zhen ^{[1
]}

Yao, Min ^{[1
,3
]}

Zhang, Xiong ^{[4
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Inst Traumat Med, Dept Burns & Plast Surg,Peoples Hosp 3, Shanghai 201900, Peoples R China

[2] Jinan Univ, Hosp 4, Dept Burns, Guangzhou 51022, Guangdong, Peoples R China

[3] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Dermatol,Wellman Ctr Photomed, Boston, MA 02114 USA

[4] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Burns & Plast Surg, Shanghai 200025, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2014年 / 2014卷

关键词：

VASCULAR SMOOTH-MUSCLE; OXIDATIVE STRESS; NOX FAMILY; GROWTH-FACTOR; NAD(P)H OXIDASES; EPITHELIAL-CELLS; MESANGIAL CELLS; MAJOR SOURCE; SUPEROXIDE; EXPRESSION;

D O I：

10.1155/2014/282854

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Reactive oxygen species are mostly viewed to cause oxidative damage to various cells and induce organ dysfunction after ischemia-reperfusion injury. However, they are also considered as crucial molecules for cellular signal transduction in biology. NADPH oxidase, whose only function is reactive oxygen species production, has been extensively investigated in many cell types especially phagocytes. The deficiency of NADPH oxidase extends the process of inflammation and delays tissue repair, which causes chronic granulomatous disease in patients. NADPH oxidase 1, one member of the NADPH oxidase family, is not only constitutively expressed in a variety of tissues, but also induced to increase expression in both mRNA and protein levels under many circumstances. NADPH oxidase 1 and its derived reactive oxygen species are suggested to be able to regulate inflammation reaction, cell proliferation and migration, and extracellular matrix synthesis, which contribute to the processes of tissue injury and repair.

引用

页数：10

共 75 条

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