Osteoclasts Pump Iron

被引：61

作者：

Roodman, G. David ^{[1
,2
]}

机构：

[1] Vet Affairs Pittsburgh Healthcare Syst, Dept Med Hematol Oncol, Pittsburgh, PA 15240 USA

[2] Univ Pittsburgh, Dept Med Hematol Oncol, Pittsburgh, PA 15260 USA

来源：

CELL METABOLISM | 2009年 / 9卷 / 05期

关键词：

DEFICIENCY;

D O I：

10.1016/j.cmet.2009.04.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Osteoclasts are the primary cells that resorb bone; they require high energy levels to degrade bone matrix, releasing minerals to maintain calcium homeostasis. Recent work on osteoclast differentiation and activity highlights an important role for mitochondrial biogenesis and explores the role of iron transferrin in generating a positive osteoclastogenic feedback loop.

引用

页码：405 / 406

页数：2

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