Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

被引：431

作者：

Vacchelli, Erika ^{[1
,2
,3
,4
,5
]}

Ma, Yuting ^{[1
,2
,3
,4
,5
,6
,7
,8
]}

Baracco, Elisa E. ^{[1
,2
,3
,9
]}

Sistigu, Antonella ^{[10
]}

Enot, David P. ^{[1
,2
,3
,11
]}

Pietrocola, Federico ^{[1
,2
,3
,9
]}

Yang, Heng ^{[1
,2
,3
,4
,5
,6
,7
,8
]}

Adjemian, Sandy ^{[1
,2
,3
]}

Chaba, Kariman ^{[1
,2
,3
,4
]}

Semeraro, Michaela ^{[1
,12
,13
]}

Signore, Michele ^{[14
]}

De Ninno, Adele ^{[15
]}

Lucarini, Valeria ^{[14
]}

Peschiaroli, Francesca ^{[14
]}

Businaro, Luca ^{[15
]}

Gerardino, Annamaria ^{[15
]}

Manic, Gwenola ^{[10
]}

Ulas, Thomas ^{[16
]}

Guenther, Patrick ^{[16
]}

Schultze, Joachim L. ^{[16
]}

Kepp, Oliver ^{[1
,2
,3
,4
,5
]}

Stoll, Gautier ^{[1
,2
,3
,4
,5
]}

Lefebvre, Celine ^{[1
,17
]}

Mulot, Claire ^{[18
,19
]}

Castoldi, Francesca ^{[1
,2
,3
,9
,20
]}

Rusakiewicz, Sylvie ^{[1
,12
,13
]}

Ladoire, Sylvain ^{[21
,22
,23
]}

Apetoh, Lionel ^{[21
,22
,23
]}

Bravo-San Pedro, Jose Manuel ^{[1
,2
,3
,4
,5
]}

Lucattelli, Monica ^{[24
]}

Delarasse, Cecile ^{[25
]}

Boige, Valerie ^{[19
,26
]}

Ducreux, Michel ^{[9
,26
]}

Delaloge, Suzette ^{[17
,27
]}

Borg, Christophe ^{[28
]}

Andre, Fabrice ^{[1
,17
,29
,30
]}

Schiavoni, Giovanna ^{[14
]}

Vitale, Ilio ^{[10
,31
]}

Laurent-Puig, Pierre ^{[18
,19
,32
]}

Mattei, Fabrizio ^{[14
]}

Zitvogel, Laurence ^{[1
,9
,12
,13
]}

Kroemer, Guido ^{[1
,2
,3
,4
,5
,11
,32
,33
]}

机构：

[1] Gustave Roussy Canc Campus, Villejuif, France

[2] INSERM, U1138, Paris, France

[3] Ctr Rech Cordeliers, Equipe Labellisee Ligue Natl Canc 11, Paris, France

[4] Univ Paris 05, Sorbonne Paris Cite, Paris, France

[5] Univ Paris 06, Paris, France

[6] Suzhou Inst Syst Med, Suzhou, Jiangsu, Peoples R China

[7] Chinese Acad Med Sci, Beijing 100730, Peoples R China

[8] Peking Union Med Coll, Beijing 100021, Peoples R China

[9] Univ Paris Saclay, Fac Med, Le Kremlin Bicetre, France

[10] Regina Elena Inst Canc Res, Rome, Italy

[11] Gustave Roussy Canc Campus, Metabol & Cell Biol Platforms, Villejuif, France

[12] INSERM, U1015, Villejuif, France

[13] Ctr Clin Invest Biotherapies Canc CICBT 507, Villejuif, France

[14] Ist Super Sanita, Dept Hematol Oncol & Mol Med, I-00161 Rome, Italy

[15] Italian Natl Res Council, Inst Photon & Nanotechnol, Rome, Italy

[16] Univ Bonn, Life & Med Sci Ctr Inst, Genom & Immunoregulat, Bonn, Germany

[17] INSERM, U981, Villejuif, France

[18] Univ Paris Sorbonne Cite, UMRS 775, INSERM, Paris, France

[19] Ctr Ressources Biol CRB EPIGENETIC, INSERM, U1147, Paris, France

[20] Sotio, Prague, Czech Republic

[21] Ctr Georges Francois Leclerc, Dept Med Oncol, Dijon, France

[22] Univ Bourgogne Franche Comte, Dijon, France

[23] Ctr Georges Francois Leclerc, Dijon, France

[24] Univ Siena, Dept Life Sci, I-53100 Siena, Italy

[25] Hop La Pitie Salpetriere, Equipe Neurogenet & Physiol, Inst Cerveau & Moelle Epiniere, ICM,CNRS,UMR 7225,INSERM,U1127,UPMC P6,UMR S 1127, F-75013 Paris, France

[26] Gustave Roussy Canc Campus, Dept Med Oncol, Villejuif, France

[27] Gustave Roussy Canc Campus, Dept Breast Oncol, Villejuif, France

[28] Univ Franche Comte, INSERM 1098, F-25030 Besancon, France

[29] Gustave Roussy Canc Campus, Dept Biol & Pathol, Villejuif, France

[30] Gustave Roussy Canc Campus, Dept Med Oncol, Villejuif, France

[31] Univ Roma Tor Vergata, Dept Biol, I-00173 Rome, Italy

[32] Hop Europeen Georges Pompidou, AP HP, Pole Biol, Paris, France

[33] Karolinska Inst, Dept Womens & Childrens Hlth, Karolinska Univ Hosp, S-17176 Stockholm, Sweden

来源：

SCIENCE | 2015年 / 350卷 / 6263期

基金：

欧洲研究理事会;

关键词：

ANTIGEN-PRESENTING CELLS; ANTICANCER CHEMOTHERAPY; BREAST-CANCER; IMMUNOSURVEILLANCE; TUMOR; INFLAMMATION; RECRUITMENT; NEUTROPHILS; MECHANISM; THERAPY;

D O I：

10.1126/science.aad0779

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Antitumor immunity driven by intratumoral dendritic cells contributes to the efficacy of anthracycline-based chemotherapy in cancer. We identified a loss-of-function allele of the gene coding for formyl peptide receptor 1 (FPR1) that was associated with poor metastasis-free and overall survival in breast and colorectal cancer patients receiving adjuvant chemotherapy. The therapeutic effects of anthracyclines were abrogated in tumor-bearing Fpr1(-/-) mice due to impaired antitumor immunity. Fpr1-deficient dendritic cells failed to approach dying cancer cells and, as a result, could not elicit antitumor T cell immunity. Experiments performed in a microfluidic device confirmed that FPR1 and its ligand, annexin-1, promoted stable interactions between dying cancer cells and human or murine leukocytes. Altogether, these results highlight the importance of FPR1 in chemotherapy-induced anticancer immune responses.

引用

页码：972 / 978

页数：7

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