Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs

被引：539

作者：

Lukyanov, AN ^{[1
]}

Torchilin, VP ^{[1
]}

机构：

[1] Northeastern Univ, Bouve Coll Hlth Sci, Sch Pharm, Dept Pharmaceut Sci, Boston, MA 02115 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2004年 / 56卷 / 09期

关键词：

amphiphilic polymers; polymer-lipid conjugates; micelles; poorly soluble drugs; anticancer drugs; solubilization; enhanced permeability and retention effect; anticancer antibody; immunomicelles; tumor drug-delivery;

D O I：

10.1016/j.addr.2003.12.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Polymeric micelles have a whole set of unique characteristics, which make them very promising drug carriers, in particular, for poorly soluble drugs. Our review article focuses on micelles prepared from conjugates of water-soluble polymers, such as polyethylene glycol (PEG) or polyvinyl pyrrolidone (PVP), with phospholipids or long-chain fatty acids. The preparation of micelles from certain polymer-lipid conjugates and the loading of these micelles with various poorly soluble anticancer agents are discussed. The data on the characterization of micellar preparations in terms of their morphology, stability, longevity in circulation, and ability to spontaneously accumulate in experimental tumors via the enhanced permeability and retention (EPR) effect are presented. The review also considers the preparation of targeted immunomicelles with specific antibodies attached to their surface. Available in vivo results on the efficiency of anticancer drugs incorporated into plain micelles and immunomicelles in animal models are also discussed. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：1273 / 1289

页数：17

共 85 条

[1]

ABUCHOWSKI A, 1979, CANCER TREAT REP, V63, P1127

[2] A MIXED MICELLAR FORMULATION SUITABLE FOR THE PARENTERAL ADMINISTRATION OF TAXOL [J].

ALKANONYUKSEL, H ;

RAMAKRISHNAN, S ;

CHAI, HB ;

PEZZUTO, JM .

PHARMACEUTICAL RESEARCH, 1994, 11 (02) :206-212

[3] Polycaprolactone-b-poly(ethylene oxide) block copolymer micelles as a novel drug delivery vehicle for neurotrophic agents FK506 and L-685,818 [J].

Allen, C ;

Yu, YS ;

Maysinger, D ;

Eisenberg, A .

BIOCONJUGATE CHEMISTRY, 1998, 9 (05) :564-572

[4]

Ansel H. C., 1999, PHARM DOSAGE FORMS D, DOI DOI 10.1016/j.ijpharm.2006.03.010

[5] TAXOL-LIPID INTERACTIONS - TAXOL-DEPENDENT EFFECTS ON THE PHYSICAL-PROPERTIES OF MODEL MEMBRANES [J].

BALASUBRAMANIAN, SV ;

STRAUBINGER, RM .

BIOCHEMISTRY, 1994, 33 (30) :8941-8947

[6]

BeduAddo FK, 1996, PHARMACEUT RES, V13, P718

[7] Novel polymeric micelles based on the amphiphilic diblock copolymer poly(N-vinyl-2-pyrrolidone)-block-poly(D,L-lactide) [J].

Benahmed, A ;

Ranger, M ;

Leroux, JC .

PHARMACEUTICAL RESEARCH, 2001, 18 (03) :323-328

[8] MOLECULAR MECHANISM OF THE LIPID VESICLE LONGEVITY INVIVO [J].

BLUME, G ;

CEVC, G .

BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1146 (02) :157-168

[9] PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases [J].

Calvo, P ;

Gouritin, B ;

Brigger, I ;

Lasmezas, C ;

Deslys, JP ;

Williams, A ;

Andreux, JP ;

Dormont, D ;

Couvreur, P .

JOURNAL OF NEUROSCIENCE METHODS, 2001, 111 (02) :151-155

[10] FATTY-ACID ACYLATED FAB-FRAGMENTS OF ANTIBODIES TO NEUROSPECIFIC PROTEINS AS CARRIERS FOR NEUROLEPTIC TARGETED DELIVERY IN BRAIN [J].

CHEKHONIN, VP ;

KABANOV, AV ;

ZHIRKOV, YA ;

MOROZOV, GV .

FEBS LETTERS, 1991, 287 (1-2) :149-152

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