In vitro evaluation of cytotoxicity of engineered metal oxide nanoparticles

被引：262

作者：

Hu, Xiaoke ^{[1
]}

Cook, Sean ^{[1
]}

Wang, Peng ^{[1
]}

Hwang, Huey-min ^{[1
]}

机构：

[1] Jackson State Univ, Dept Biol, Jackson, MS 39217 USA

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2009年 / 407卷 / 08期

基金：

美国国家科学基金会;

关键词：

Cytotoxicity; Metal oxide nanoparticles; LD50; ACUTE TOXICITY; EXPOSURE;

D O I：

10.1016/j.scitotenv.2009.01.033

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The recent advances in nanotechnology and the corresponding popular usage of nanomaterials have resulted in uncertainties regarding their environmental impacts. In this study, we used a systematic approach to study and compare the in vitro cytotoxicity of selected engineered metal oxide nanoparticles to the test organisms E coli. Among the seven test nano-sized metal oxides, ZnO, CuO, Al2O3, La2O3, Fe2O3, SnO2 and TiO2, ZnO showed the lowest LD50 of 21.1 mg/L and TiO2 had the highest LD50 of 1104.8 mg/L Data of C-14-glucose mineralization test paralleled the results of bacteria viability test. After regression calculation, the cytotoxicity was found to be 2 correlated with cation charges (R-2 = 0.9785). The higher the cation charge is, the lower the cytotoxicity of the nano-sized metal oxide becomes. To the best of our knowledge, this finding is the first report in nanotoxicology. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：3070 / 3072

页数：3

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