Sulfation of a polysaccharide obtained from Phellinus ribis and potential biological activities of the sulfated derivatives

被引：117

作者：

Liu, Yuhong ^{[1
,2
,3
]}

Liu, Chunhui ^{[1
,2
]}

Tan, Haining ^{[2
]}

Zhao, Ting ^{[1
]}

Cao, Jichao ^{[1
]}

Wang, Fengshan ^{[1
,2
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Inst Biochem & Biotechnol Drugs, Jinan 250012, Peoples R China

[2] Shandong Univ, Natl Glycoengn Res Center, Jinan 250012, Peoples R China

[3] Shandong Univ Tradit Chinese Med, Jinan 250355, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2009年 / 77卷 / 02期

关键词：

Phellinus ribis; Polysaccharide; Sulfation; Antitumor; Anti-angiogenic activities; IN-VITRO; ANTICOAGULANT; ANGIOGENESIS; CANCER; CARRAGEENANS; ANTITUMOR; ALGA;

D O I：

10.1016/j.carbpol.2009.01.008

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The paper reports the preparation, characterization and potential biological activities of a chemically sulfated polysaccharide isolated from Phellinus ribis. Four sulfated derivatives (PRP-SI-IV) with variable degrees of substitution were obtained by the chlorosulfonic acid method, without degradation of the polysaccharide (PRP). The sulfate groups were not regularly distributed along the polysaccharide chain with a multiple substitution pattern as determined by C-13 NMR. The sulfated derivatives except for PRP-SI showed significant inhibition effects on HepG2 cells in comparison with the native non-sulfated polysaccharide (PRP). All sulfated derivatives could block new angiogenic vessel formation in zebrafish assay, however, the effects were less than PRP. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：370 / 375

页数：6

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