bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations

被引：197

作者：

Chen, J

Flannery, JG

LaVail, MM

Steinberg, RH

Xu, J

Simon, MI

机构：

[1] UNIV SO CALIF,SCH MED,DOHENY EYE INST,DEPT OPHTHALMOL & CELL & NEUROBIOL,LOS ANGELES,CA 90033

[2] UNIV CALIF BERKELEY,SCH OPTOMETRY,BERKELEY,CA 94720

[3] UNIV CALIF SAN FRANCISCO,BECKMAN VIS CTR,SAN FRANCISCO,CA 94143

[4] CADUS PHARMACEUT CORP,TARRYTOWN,NY 10591

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1996年 / 93卷 / 14期

关键词：

apoptosis; transgenic mice; retina;

D O I：

10.1073/pnas.93.14.7042

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Apoptosis of photoreceptors occurs infrequently in adult retina but can be triggered in inherited and environmentally induced retinal degenerations. The protooncogene bcl-2 is known to be a potent regulator of cell survival in neurons. We created lines of transgenic mice overexpressing bcl-2 to test for its ability to increase photoreceptor survival, bcl-2 increased photoreceptor survival in mice with retinal degeneration caused by a defective opsin or cGMP phosphodiesterase. Overexpression of Bcl-2 in normal photoreceptors also decreased the damaging effects of constant light exposure. Apoptosis was induced in normal photoreceptors by very high levels of bcl-2. We conclude that bcl-2 is an important regulator of photoreceptor cell death in retinal degenerations.

引用

页码：7042 / 7047

页数：6

共 31 条

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