Role of infiltrated leucocytes in tumour growth and spread

被引：229

作者：

Lin, EY

Pollard, JW

机构：

[1] Albert Einstein Coll Med, Dept Dev & Mol Biol, Ctr Study Reprod Biol & Womens Hlth, Albert Einstein Canc Ctr, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Obstet & Gynecol, Ctr Study Reprod Biol & Womens Hlth, Albert Einstein Canc Ctr, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Dept Womens Hlth, Ctr Study Reprod Biol & Womens Hlth, Albert Einstein Canc Ctr, Bronx, NY 10461 USA

来源：

BRITISH JOURNAL OF CANCER | 2004年 / 90卷 / 11期

关键词：

leucocyte; tumour; progression; metastasis; angiogenesis;

D O I：

10.1038/sj.bjc.6601705

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Leucocytes are a major component of the tumour microenvironment. Recent studies have indicated that the infiltration and activity of these host cells are regulated by the tumour to promote its survival and progression. Through the production of an array of growth factors, proteases and angiogenic mediators, leucocytes in the tumour microenvironment promote tumour growth, angiogenesis and metastasis. (C) 2004 Cancer Research UK.

引用

页码：2053 / 2058

页数：6

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