Emerging cross-regulatory roles of immunity and autoimmunity in atherosclerosis

被引：18

作者：

George, J

Harats, D

Gilburd, B

Shoenfeld, Y

机构：

[1] CHAIM SHEBA MED CTR,DEPT MED B,IL-52621 TEL HASHOMER,ISRAEL

[2] CHAIM SHEBA MED CTR,AUTOIMMUNE DIS RES UNIT,IL-52621 TEL HASHOMER,ISRAEL

[3] CHAIM SHEBA MED CTR,INST LIPID & ATHEROSCLEROSIS RES,IL-52621 TEL HASHOMER,ISRAEL

来源：

IMMUNOLOGIC RESEARCH | 1996年 / 15卷 / 04期

关键词：

atherosclerosis; autoimmunity; oxidized low density lipoprotein; heat shock protein 60/65;

D O I：

10.1007/BF02935315

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Atherosclerosis is a histopathological process of a multifactorial origin. Whereas the genetic and biochemical causes received considerable attention, the involvement of the immune system has generally been considered negligible. In recent years evidence has been presented to support the dominant role played by the immune system in atherosclerosis. Two major antigenic determinants against which the immune response may be triggered have been suggested, namely the heat shock protein 60/65 and oxidized low density lipoprotein. The current paper reviews the data regarding the involvement of the immune system in atherogenesis with respect to the antigenic candidates mentioned above.

引用

页码：315 / 322

页数：8

共 42 条

[1] Immunization with cholesterol-rich liposomes induces anti-cholesterol antibodies and reduces diet-induced hypercholesterolemia and plaque formation [J].