A study on the perturbation of model lipid membranes by phenoxazines

被引：20

作者：

Hendrich, Andrzej B. ^{[1
]}

Stanczak, Kamila

Komorowska, Malgorzata

Motohashi, Noboru

Kawase, Masami

Michalak, Krystyna

机构：

[1] Wroclaw Med Univ, Dept Biophys, Wroclaw, Poland

[2] Wroclaw Univ Technol, Inst Phys, Wroclaw, Poland

[3] Meiji Pharmaceut Univ, Koyose, Tokyo 2048588, Japan

[4] Josai Univ, Fac Pharmaceut Sci, Sakado, Saitama 3500295, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 17期

关键词：

phenoxazine; lipid bilayer; fluidity; fluorescence spectroscopy; microcalorimetry;

D O I：

10.1016/j.bmc.2006.05.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interactions of six newly synthesized phenoxazine derivatives with lipid bilayers were studied by means of calorimetry, fluorescence spectroscopic methods and electron spin resonance. Depending on their structure studied compounds decreased membrane fluidity and increased lipid order in liquid-crystalline bilayers to different degrees. These studies showed also that phenoxazine molecules are located close to the polar/apolar interface of bilayer. The results allow to conclude that phenoxazines rather weakly interact with lipid bilayers. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5948 / 5954

页数：7

共 30 条

[1] Cancer chemopreventive effect of phenothiazines and related tri-heterocyclic analogues in the 12-O-tetradecanoylphorbol-13-acetate promoted Epstein-Barr virus early antigen activation and the mouse skin two-stage carcinogenesis models [J].