Immobilized hyperbranched glycoacrylate films as bioactive supports

被引：32

作者：

Muthukrishnan, Sharmila

Nitschke, Mirko

Gramm, Stefan

Oezyuerek, Zeynep

Voit, Brigitte

Werner, Carsten

Mueller, Axel H. E.

机构：

[1] Univ Bayreuth, Bayreuther Zentrum Kolloide & Grenzflachen, D-95440 Bayreuth, Germany

[2] Max Bergmann Ctr Biomat, Leibniz Inst Polymer Res Dresden, D-01069 Dresden, Germany

来源：

MACROMOLECULAR BIOSCIENCE | 2006年 / 6卷 / 08期

关键词：

atom transfer radical polymerization (ATRP); bioactive; biomaterials; fibronectin; glycopolymers; proliferation; tissue engineering;

D O I：

10.1002/mabi.200600064

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report on the low-pressure plasma immobilization, characterization and application of thin films of hyperbranched glycoacrylates, poly(3-O-acryloyl-alpha, beta-D-glucopyranoside) (AGlc), on PTFE-like fluorocarbon surfaces. This method is an efficient and versatile way to immobilize sugar-carrying branched acrylates as thin films of approximately 5 nm thickness on polymeric substrates while the functional groups and properties of the immobilized molecules are largely retained. The extent of poly(AGlc) degradation during plasma immobilization was investigated using FTIR-ATR spectroscopy and XPS. The thickness and topography of the immobilized films were characterized using spectroscopic ellipsometry and SFM, respectively. Studies of protein adsorption, as well as cell adhesion and proliferation on the poly(AGlc) surfaces, showed that these materials are suitable for the control of biointerfacial phenomena.

引用

页码：658 / 666

页数：9

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