MARS spectral molecular imaging of lamb tissue: data collection and image analysis

被引：42

作者：

Aamir, R. ^{[1
]}

Chernoglazov, A. ^{[2
]}

Bateman, C. J. ^{[1
]}

Butler, A. P. H. ^{[1
,3
,4
,5
,6
]}

Butler, P. H. ^{[3
,5
]}

Anderson, N. G. ^{[1
]}

Bell, S. T. ^{[5
]}

Panta, R. K. ^{[1
]}

Healy, J. L. ^{[7
]}

Mohr, J. L. ^{[1
]}

Rajendran, K. ^{[1
]}

Walsh, M. F. ^{[1
]}

de Ruiter, N. ^{[2
]}

Gieseg, S. P. ^{[7
]}

Woodfield, T. ^{[8
]}

Renaud, P. F. ^{[9
]}

Brooke, L. ^{[6
]}

Abdul-Majid, S. ^{[10
]}

Clyne, M. ^{[11
]}

Glendenning, R. ^{[12
]}

Bones, P. J. ^{[4
]}

Billinghurst, M. ^{[2
]}

Bartneck, C. ^{[2
]}

Mandalika, H. ^{[2
]}

Grasset, R. ^{[2
]}

Schleich, N. ^{[13
]}

Scott, N. ^{[14
]}

Nik, S. J. ^{[6
]}

Opie, A. ^{[4
]}

Janmale, T. ^{[7
]}

Tang, D. N. ^{[6
]}

Kim, D. ^{[6
]}

Doesburg, R. M. ^{[3
,6
]}

Zainon, R. ^{[6
]}

Ronaldson, J. P. ^{[1
]}

Cook, N. J. ^{[15
]}

Smithies, D. J. ^{[6
]}

Hodge, K. ^{[1
]}

机构：

[1] Univ Otago, Dept Radiol, Ctr Bioengn, Christchurch, New Zealand

[2] Univ Canterbury, HIT Lab NZ, Christchurch 1, New Zealand

[3] CERN, Geneva, Switzerland

[4] Univ Canterbury, Dept Elect & Comp Engn, Christchurch 1, New Zealand

[5] MARS Bioimaging Ltd, Christchurch, New Zealand

[6] Univ Canterbury, Dept Phys & Astron, Christchurch 1, New Zealand

[7] Univ Canterbury, Dept Biochem, Christchurch 1, New Zealand

[8] Univ Otago, Dept Orthopaed Surg & MSM, Christchurch, New Zealand

[9] Univ Canterbury, Dept Math & Stat, Christchurch 1, New Zealand

[10] King Abdulaziz Univ, Dept Nucl Engn, Jeddah 21413, Saudi Arabia

[11] ILR, Christchurch, New Zealand

[12] Scott Technol Ltd, Christchurch, New Zealand

[13] Univ Otago, Dept Radiat Therapy, Wellington, New Zealand

[14] Univ Otago, Dept Med, Christchurch, New Zealand

[15] CDHB, Dept Med Phys & Bioengn, Christchurch, New Zealand

来源：

JOURNAL OF INSTRUMENTATION | 2014年 / 9卷

关键词：

X-ray detectors; Computerized Tomography (CT) and Computed Radiography (CR); Medical-image reconstruction methods and algorithms; computer-aided diagnosis; Data acquisition concepts; RAY; CT;

D O I：

10.1088/1748-0221/9/02/P02005

中图分类号：

TH7 [仪器、仪表];

学科分类号：

080401 [精密仪器及机械];

摘要：

Spectral molecular imaging is a new imaging technique able to discriminate and quantify different components of tissue simultaneously at high spatial and high energy resolution. Our MARS scanner is an x-ray based small animal CT system designed to be used in the diagnostic energy range (20-140 keV). In this paper, we demonstrate the use of the MARS scanner, equipped with the Medipix3RX spectroscopic photon-processing detector, to discriminate fat, calcium, and water in tissue. We present data collected from a sample of lamb meat including bone as an illustrative example of human tissue imaging. The data is analyzed using our 3D Algebraic Reconstruction Algorithm (MARS-ART) and by material decomposition based on a constrained linear least squares algorithm. The results presented here clearly show the quantification of lipid-like, water-like and bone-like components of tissue. However, it is also clear to us that better algorithms could extract more information of clinical interest from our data. Because we are one of the first to present data from multi-energy photon-processing small animal CT systems, we make the raw, partial and fully processed data available with the intention that others can analyze it using their familiar routines. The raw, partially processed and fully processed data of lamb tissue along with the phantom calibration data can be found at http://hdl.handle.net/10092/8531.

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页数：12

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