Torsades do Pointes associated with nonantiarrhythmic drugs and observations on gender and QTc

被引：85

作者：

Bednar, MM

Harrigan, EP

Ruskin, JN ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Boston, MA 02114 USA

[2] Pfizer Global Res & Dev, Groton, CT USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2002年 / 89卷 / 11期

关键词：

D O I：

10.1016/S0002-9149(02)02337-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The reported occurrence of torsades de pointes in association with nonantiarrhythmic drugs (n = 189) suggests that >90% of events occur in association with QTc values greater than or equal to500 ms and that women accounted for approximately two thirds of all reported cases. Both observations are extremely similar to the findings reported in a large database (n = 332) for antiarrhythmic agents, suggesting a fundamental biologic response that transcends both drug class and population studied.

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页码：1316 / +

页数：5

相关论文

共 19 条

[1]

Bazett HC, 1920, HEART-J STUD CIRC, V7, P353

[2] Greater quinidine-induced QTc interval prolongation in women [J].

Benton, RE ;

Sale, M ;

Flockhart, DA ;

Woosley, RL .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2000, 67 (04) :413-418

[3] Gender-specific differences in the QT interval and the effect of autonomic tone and menstrual cycle in healthy adults [J].

Burke, JH ;

Ehlert, FA ;

Kruse, JT ;

Parker, MA ;

Goldberger, JJ ;

Kadish, AH .

AMERICAN JOURNAL OF CARDIOLOGY, 1997, 79 (02) :178-181

[4] Cardiac actions of erythromycin - Influence of female sex [J].

Drici, MD ;

Knollmann, BC ;

Wang, WX ;

Woosley, RL .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (20) :1774-1776

[5]

Ebert SN, 2000, MONOPHASIC ACTION POTENTIALS: BRIDGING CELL AND BEDSIDE, P659

[6] Effects of gender on cardiac arrhythmias [J].

Larsen, JA ;

Kadish, AH .

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 1998, 9 (06) :655-664

[7]

Liu XK, 1998, J PHARMACOL EXP THER, V285, P672

[8] Age- and sex-related differences in clinical manifestations in patients with congenital long-QT syndrome - Findings from the international LQTS registry [J].

Locati, EH ;

Zareba, W ;

Moss, AJ ;

Schwartz, PJ ;

Vincent, GM ;

Lehmann, MH ;

Towbin, JA ;

Priori, SG ;

Napolitano, C ;

Robinson, JL ;

Andrews, M ;

Timothy, K ;

Hall, WJ .

CIRCULATION, 1998, 97 (22) :2237-2244

[9] Are there sex-specific differences in ventricular repolarization or in drug-induced early afterdepolarizations in isolated rabbit Purkinje fibers? [J].

Lu, HR ;

Mariën, R ;

Saels, A ;

De Clerck, F .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2000, 36 (01) :132-139

[10] FEMALE GENDER AS A RISK FACTOR FOR TORSADES-DE-POINTES ASSOCIATED WITH CARDIOVASCULAR DRUGS [J].

MAKKAR, RR ;

FROMM, BS ;

STEINMAN, RT ;

MEISSNER, MD ;

LEHMANN, MH .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 270 (21) :2590-2597