CHOP is involved in neuronal apoptosis induced by neurotrophic factor deprivation

被引：60

作者：

Tajiri, Seiji

Yano, Shigetoshi

Morioka, Motohiro

Kuratsu, Jun-ichi

Mori, Masataka

Gotoh, Tomomi

机构：

[1] Kumamoto Univ, Grad Sch Med Sci, Dept Neurosurg, Kumamoto 8608556, Japan

[2] Kumamoto Univ, Grad Sch Med Sci, Dept Mol Genet, Kumamoto 8608556, Japan

来源：

FEBS LETTERS | 2006年 / 580卷 / 14期

关键词：

apoptosis; C/EBP homologues protein; endoplasmic reticulum stress; neurotrophic factor; subventricular zone;

D O I：

10.1016/j.febslet.2006.05.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurotrophic factors are essential for the survival of neurons. We found that the endoplasmic reticulum (ER) stress-C/EBP homologues protein (CHOP) pathway to be activated during neurotrophic factor deprivation-induced apoptosis in PC12 neuronal cells and in primary cultured neurons, and this apoptosis was suppressed in the neurons from chop(-/-) mice. In addition, we found that CHOP is expressed in the subventricular zone (SVZ) and striatum of the young adult mouse brain. The number of apoptotic cells in the SVZ decreased in chop(-/-) mice. These results indicate that the ER stress-CHOP pathway plays a role in neuronal apoptosis during the development of the brain. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3462 / 3468

页数：7

共 34 条

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