Probiotics for prevention of recurrent urinary tract infections in women - A review of the evidence from microbiological and clinical studies

被引:93
作者
Falagas, Matthew E.
Betsi, Gregoria I.
Tokas, Theodoros
Athanasiou, Stavros
机构
[1] Alfa Inst Biomed Sci, Maroussi 15123, Greece
[2] Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA
[3] Univ Athens, Sch Med, Dept Obstet & Gynecol, GR-11527 Athens, Greece
关键词
D O I
10.2165/00003495-200666090-00007
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Recurrent urinary tract infections (UTIs) afflict a great number of women around the world. The use of probiotics, especially lactobacilli, has been considered for the prevention of UTIs. Since lactobacilli dominate the urogenital flora of healthy premenopausal women, it has been suggested that restoration of the urogenital flora, which is dominated by uropathogens, with lactobacilli may protect against UTIs. This review is based on a search of PubMed for relevant articles. Many in vitro studies, animal experiments, microbiological studies in healthy women, and clinical trials in women with UTIs have been carried out to assess the effectiveness and safety of probiotics for prophylaxis against uropathogens. Most of them had encouraging findings for some specific strains of lactobacilli. Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 (previously called L fermentum RC-14) seemed to be the most effective among the studied lactobacilli for the prevention of UTIs. L. casei shirota and L crispatus CTV-05 have also shown efficacy in some studies. L. rhamnosus GG did not appear to be quite as effective in the prevention of UTIs. The evidence from the available studies suggests that probiotics can be beneficial for preventing recurrent UTIs in women; they also have a good safety profile. However, further research is needed to confirm these results before the widespread use of probiotics for this indication can be recommended.
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页码:1253 / 1261
页数:9
相关论文
共 46 条
[1]   ON THE SAFETY OF LACTIC-ACID BACTERIA FROM FOOD [J].
ADAMS, MR ;
MARTEAU, P .
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 1995, 27 (2-3) :263-264
[2]   Lactobacillus as a probiotic for preventing urogenital infections [J].
Andreu, A .
REVIEWS IN MEDICAL MICROBIOLOGY, 2004, 15 (01) :1-6
[3]   The identification of vaginal Lactobacillus species and the demographic and microbiologic characteristics of women colonized by these species [J].
Antonio, MAD ;
Hawes, SE ;
Hillier, SL .
JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (06) :1950-1956
[4]   Antimicrobial activity of intraurethrally administered probiotic Lactobacillus casei in a murine model of Escherichia coli urinary tract infection [J].
Asahara, T ;
Nomoto, K ;
Watanuki, M ;
Yokokura, T .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (06) :1751-1760
[5]  
Baerheim Anders, 1994, Scandinavian Journal of Primary Health Care, V12, P239, DOI 10.3109/02813439409029247
[6]   Safety of probiotics that contain lactobacilli or bifidobacteria [J].
Borriello, SP ;
Hammes, WP ;
Holzapfel, W ;
Marteau, P ;
Schrezenmeir, J ;
Vaara, M ;
Valtonen, V .
CLINICAL INFECTIOUS DISEASES, 2003, 36 (06) :775-780
[7]   INTRAVAGINAL INSTILLATION OF LACTOBACILLI FOR PREVENTION OF RECURRENT URINARY-TRACT INFECTIONS [J].
BRUCE, AW ;
REID, G .
CANADIAN JOURNAL OF MICROBIOLOGY, 1988, 34 (03) :339-343
[8]  
BRUCE AW, 1973, CAN MED ASSOC J, V108, P973
[9]   Improved understanding of the bacterial vaginal microbiota of women before and after probiotic instillation [J].
Burton, JP ;
Cadieux, PA ;
Reid, G .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2003, 69 (01) :97-101
[10]  
CARDIEUX P, 2002, JAMA-J AM MED ASSOC, V287, P1940