Diagnostic Criteria for Vascular Cognitive Disorders A VASCOG Statement

被引：687

作者：

Sachdev, Perminder ^{[1
,2
]}

Kalaria, Raj ^{[3
]}

O'Brien, John ^{[4
]}

Skoog, Ingmar ^{[5
]}

Alladi, Suvarna ^{[6
]}

Black, Sandra E. ^{[7
,8
]}

Blacker, Deborah ^{[10
]}

Blazer, Dan G. ^{[11
]}

Chen, Christopher ^{[12
]}

Chui, Helena ^{[13
,14
]}

Ganguli, Mary ^{[15
,16
]}

Jellinger, Kurt ^{[17
]}

Jeste, Dilip V. ^{[18
]}

Pasquier, Florence ^{[19
,20
]}

Paulsen, Jane ^{[21
]}

Prins, Niels ^{[22
,23
]}

Rockwood, Kenneth ^{[9
]}

Roman, Gustavo ^{[24
]}

Scheltens, Philip ^{[22
,23
]}

机构：

[1] Univ New S Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia

[2] Prince Wales Hosp, Neuropsychiat Inst, Sydney, NSW 2031, Australia

[3] Newcastle Univ, Inst Ageing & Hlth, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[4] Univ Cambridge, Dept Psychiat, Cambridge, England

[5] Univ Gothenburg, Dept Psychiat & Neurochem, Gothenburg, Sweden

[6] Nizams Inst Med Sci, Dept Neurol, Hyderabad, Andhra Pradesh, India

[7] Univ Toronto, Toronto, ON, Canada

[8] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada

[9] Dalhousie Univ, Halifax, NS, Canada

[10] Harvard Univ, Sch Med, Dept Epidemiol, Boston, MA USA

[11] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC USA

[12] Natl Univ Hlth Syst, Memory Aging & Cognit Ctr, Singapore, Singapore

[13] Univ So Calif, Dept Neurol, Los Angeles, CA USA

[14] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA

[15] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA

[16] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA

[17] Inst Clin Neurobiol, Vienna, Austria

[18] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA

[19] Univ Lille Nord France UDSL, Lille, France

[20] CHU, Memory Clin, Lille, France

[21] Univ Iowa, Carver Coll Med, Iowa City, IA USA

[22] Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands

[23] Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Amsterdam, Netherlands

[24] Methodist Neurol Inst, Houston, TX USA

来源：

ALZHEIMER DISEASE & ASSOCIATED DISORDERS | 2014年 / 28卷 / 03期

基金：

澳大利亚研究理事会; 新加坡国家研究基金会; 加拿大健康研究院; 美国国家卫生研究院; 英国医学研究理事会; 加拿大创新基金会; 中国国家自然科学基金;

关键词：

vascular dementia; vascular cognitive disorder; vascular cognitive impairment; diagnostic criteria; cerebrovascular disease; multi-infarct dementia; poststroke dementia; subcortical dementia; SMALL VESSEL DISEASE; WHITE-MATTER CHANGES; ALZHEIMERS ASSOCIATION WORKGROUPS; NATIONAL INSTITUTE; RISK-FACTORS; CLINICAL DETERMINANTS; DEMENTIA; IMPAIRMENT; STROKE; BRAIN;

D O I：

10.1097/WAD.0000000000000034

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Background: Several sets of diagnostic criteria have been published for vascular dementia since the 1960s. The continuing ambiguity in vascular dementia definition warrants a critical reexamination. Methods: Participants at a special symposium of the International Society for Vascular Behavioral and Cognitive Disorders (VASCOG) in 2009 critiqued the current criteria. They drafted a proposal for a new set of criteria, later reviewed through multiple drafts by the group, including additional experts and the members of the Neurocognitive Disorders Work Group of the fifth revision of Diagnostic and Statistical Manual (DSM-5) Task Force. Results: Cognitive disorders of vascular etiology are a heterogeneous group of disorders with diverse pathologies and clinical manifestations, discussed broadly under the rubric of vascular cognitive disorders (VCD). The continuum of vascular cognitive impairment is recognized by the categories of Mild Vascular Cognitive Disorder, and Vascular Dementia or Major Vascular Cognitive Disorder. Diagnostic thresholds are defined. Clinical and neuroimaging criteria are proposed for establishing vascular etiology. Subtypes of VCD are described, and the frequent cooccurrence of Alzheimer disease pathology emphasized. Conclusions: The proposed criteria for VCD provide a coherent approach to the diagnosis of this diverse group of disorders, with a view to stimulating clinical and pathologic validation studies. These criteria can be harmonized with the DSM-5 criteria such that an international consensus on the criteria for VCD may be achieved.

引用

页码：206 / 218

页数：13

共 85 条

[1]

The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].