The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists

被引:29
作者
Hale, JJ [1 ]
Doherty, G
Toth, L
Li, Z
Mills, SG
Hajdu, R
Keohane, CA
Rosenbach, M
Milligan, J
Shei, GJ
Chrebet, G
Bergstrom, J
Card, D
Rosen, H
Mandala, S
机构
[1] Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA
[2] Merck Res Labs, Dept Immunol & Rheumatol Res, Rahway, NJ 07065 USA
关键词
D O I
10.1016/j.bmcl.2004.04.069
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
3-(N-Alkyl)aminopropylphosphonic acids are potent agonists of four of the five known sphingosine-1-phosphate (S1P) receptor subtypes. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:3495 / 3499
页数:5
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