Moderate overexpression of AIB1 triggers pre-neoplastic changes in mammary epithelium

被引：15

作者：

Avivar, Alvaro

Garcia-Macias, Maria Carmen

Ascaso, Emma

Herrera, Guadalupe

O'Connor, Jose-Enrique

de Mora, Jaime Font

机构：

[1] Ctr Invest Principe Felipe, Lab Cellular & Mol Biol, Valencia 46013, Spain

[2] UVEG, CIPF, Lab Cytom, Mixed Unit, Valencia 46013, Spain

[3] Univ Hosp Salamanca, Dept Pathol, Salamanca 47007, Spain

来源：

FEBS LETTERS | 2006年 / 580卷 / 22期

关键词：

AIB1; mammary hyperplasia; nuclear transport; E-cadherin;

D O I：

10.1016/j.febslet.2006.08.057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here we report a new model of pre-clinical breast cancer which has been generated by overexpressing the steroid receptor coactivator AIB1 at moderate levels in breast epithelium. Transgenic female mice display mammary hyperplasia at the onset of puberty, consistent with enhanced proliferation of primary mammary epithelial cultures and augmented levels of cyclin D1 and E-cadherin. Studies of BrdU incorporation revealed that AIB1 localizes to the nucleus during or after S phase, implicating a new role for AIB1 in cell-cycle progression subsequent to G1. Our findings suggest that moderate overexpression of AIB1 may represent one of the pre-neoplastic changes in breast tissue. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：5222 / 5226

页数：5

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