Differential regulation of melanin-concentrating hormone and orexin genes in the agouti-related protein/melanocortin-4 receptor system

被引：73

作者：

Hanada, R

Nakazato, M

Matsukura, S

Murakami, N

Yoshimatsu, H

Sakata, T ^{[1
]}

机构：

[1] Oita Med Univ, Sch Med, Dept Internal Med 1, Oita 8795593, Japan

[2] Miyazaki Med Coll, Dept Internal Med 3, Miyazaki 8891692, Japan

[3] Miyazaki Univ, Fac Agr, Dept Vet Physiol, Miyazaki 8891692, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 268卷 / 01期

关键词：

D O I：

10.1006/bbrc.1999.2081

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Agouti protein and agouti-related protein (AGRP) antagonize alpha-melanocyte;stimulating hormone that binds to and activates the melanocortin-4 receptor (MC4-R) in the hypothalamus, thereby stimulating food intake. Melanin-concentrating hormone (MICH) and orexin are orexigenic peptides that specifically are synthesized in the lateral hypothalamus. MCH gene expression was augmented in A(y)/a (agouti) mice which overexpress agouti protein, but orexin mRNA was not. AGRP administered intracerebroventricularly into wild-type rats augmented MCH hut not orexin gene expression. Also, SHCT9119, a peptidergic antagonist of MC4-R, increased only MCH mRNA. These findings indicate that interruption of signaling at MC4-R activates the MCH but not the orexin gene. The biosyntheses of MCH and orexin are regulated through different pathways. (C) 2000 Academic Press.

引用

页码：88 / 91

页数：4

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