Regulatory T cells in transplantation

被引：51

作者：

Karim, M ^{[1
]}

Bushell, AR ^{[1
]}

Wood, KJ ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(02)00379-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There has recently been an explosion of renewed interest in regulatory T cells, particularly those within the CD4(+)CD25(+) population. It is becoming increasingly apparent that these cells exist not only as naturally occurring cells that may contribute to the maintenance of self-tolerance, but they also have the potential to prevent rejection of allografts in experimental models. Such cells have now been identified in humans as well as in rodents. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：584 / 591

页数：8

共 80 条

[61]

Stephens LA, 2001, EUR J IMMUNOL, V31, P1247, DOI 10.1002/1521-4141(200104)31:4<1247::AID-IMMU1247>3.0.CO

[62]

2-M

[63] CD4+CD25+ T-cell development is regulated by at least 2 distinct mechanisms [J].

Suto, A ;

Nakajima, H ;

Ikeda, K ;

Kubo, S ;

Nakayama, T ;

Taniguchi, M ;

Saito, Y ;

Iwamoto, I .

BLOOD, 2002, 99 (02) :555-560

[64]

Taams LS, 2001, EUR J IMMUNOL, V31, P1122, DOI 10.1002/1521-4141(200104)31:4<1122::AID-IMMU1122>3.0.CO

[65]

2-P

[66] Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells:: induction of autoimmune disease by breaking their anergic/suppressive state [J].

Takahashi, T ;

Kuniyasu, Y ;

Toda, M ;

Sakaguchi, N ;

Itoh, M ;

Iwata, M ;

Shimizu, J ;

Sakaguchi, S .

INTERNATIONAL IMMUNOLOGY, 1998, 10 (12) :1969-1980

[67] Immunologic self-tolerance maintained by CD25+CD4+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4 [J].

Takahashi, T ;

Tagami, T ;

Yamazaki, S ;

Uede, T ;

Shimizu, J ;

Sakaguchi, N ;

Mak, TW ;

Sakaguchi, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (02) :303-309

[68] In vitro induction of CD25+ CD4+ regulatory T cells by the neuropeptide alpha-melanocyte stimulating hormone (α-MSH) [J].

Taylor, AW ;

Namba, K .

IMMUNOLOGY AND CELL BIOLOGY, 2001, 79 (04) :358-367

[69] CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production [J].

Thornton, AM ;

Shevach, EM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (02) :287-296

[70] Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific [J].

Thornton, AM ;

Shevach, EM .

JOURNAL OF IMMUNOLOGY, 2000, 164 (01) :183-190

← 1 2 3 4 5 6 7 8 →