Signal transduction - Mad about SMADs

被引：49

作者：

Wrana, J

Pawson, T

机构：

[1] HOSP SICK CHILDREN,DIV GASTROENTEROL,TORONTO,ON M5G 1X8,CANADA

[2] MT SINAI HOSP,SAMUEL LUNENFELD RES INST,PROGRAM MOL BIOL & CANC,TORONTO,ON M5G 1X8,CANADA

来源：

NATURE | 1997年 / 388卷 / 6637期

关键词：

D O I：

10.1038/40290

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Signalling through the transforming growth factor-beta (TGF-beta) requires the so-called Smad proteins, and two papers now show how the Smads work. TGF-beta binds to its receptor, which then activates Smad2 to form a transcriptionally active complex with Smad4. But the crystal structure of Smad4 shows that its carboxy-terminal domain can join up with its amino-terminal domain, to prevent the formation of a complex and, hence, to inhibit TGF-beta- mediated signalling.

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收藏

页码：28 / 29

页数：2

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