Longitudinal Inflammation, Cognitive Decline, and Alzheimer's Disease: A Mini-Review

被引：82

作者：

Bettcher, B. M. ^{[1
]}

Kramer, J. H. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2014年 / 96卷 / 04期

关键词：

C-REACTIVE PROTEIN; OLDEST-OLD; METABOLIC SYNDROME; SYSTEMIC INFLAMMATION; DEMENTIA; RISK; SERUM; INTERLEUKIN-6; PROGRESSION; POPULATION;

D O I：

10.1038/clpt.2014.147

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The role of inflammation in cognitive decline has generated considerable interest, although few longitudinal evaluations have been conducted. A review of the literature yields mixed findings but suggests that inflammatory dysregulation is evident and may be related to clinical outcomes. The directionality, magnitude, and progression of these associations remain unclear. Future studies employing multiple time points of inflammatory data along with Alzheimer's disease (AD) biomarkers are critical for explication of longitudinal inflammation in cognitive decline.

引用

页码：464 / 469

页数：6

共 39 条

[1] High-sensitivity C-reactive protein is associated with hippocampus volume in nondementia patients with type 2 diabetes mellitus [J].

Anan, Futoshi ;

Masaki, Takayuki ;

Shimomura, Tsuyoshi ;

Fujiki, Minoru ;

Umeno, Yoshikazu ;

Eshima, Nobuoki ;

Saikawa, Tetsunori ;

Yoshimatsu, Hironobu .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2011, 60 (04) :460-466

[2] Relation of NSAIDs to incident AD, change in cognitive function, and AD pathology [J].

Arvanitakis, Z. ;

Grodstein, F. ;

Bienias, J. L. ;

Schneider, J. A. ;

Wilson, R. S. ;

Kelly, J. F. ;

Evans, D. A. ;

Bennett, D. A. .

NEUROLOGY, 2008, 70 (23) :2219-2225

[3] C-reactive protein is related to memory and medial temporal brain volume in older adults [J].

Bettcher, Brianne Magouirk ;

Wilheim, Reva ;

Rigby, Taylor ;

Green, Ralph ;

Miller, Joshua W. ;

Racine, Caroline A. ;

Yaffe, Kristine ;

Miller, Bruce L. ;

Kramer, Joel H. .

BRAIN BEHAVIOR AND IMMUNITY, 2012, 26 (01) :103-108

[4] Soluble TNF receptors are associated with Aβ metabolism and conversion to dementia in subjects with mild cognitive impairment [J].

Buchhave, Peder ;

Zetterberg, Henrik ;

Blennow, Kaj ;

Minthon, Lennart ;

Janciauskiene, Sabina ;

Hansson, Oskar .

NEUROBIOLOGY OF AGING, 2010, 31 (11) :1877-1884

[5] Systemic inflammation and delirium: important co-factors in the progression of dementia [J].

Cunningham, Colm .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2011, 39 :945-953

[6] Serum inflammatory proteins and cognitive decline in older persons [J].

Dik, MG ;

Jonker, C ;

Hack, CE ;

Smit, JH ;

Comijs, HC ;

Eikelenboom, P .

NEUROLOGY, 2005, 64 (08) :1371-1377

[7] Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease [J].

Eikelenboom, Piet ;

Hoozemans, Jeroen J. M. ;

Veerhuis, Rob ;

van Exel, Eric ;

Rozemuller, Annemieke J. M. ;

van Gool, Willem A. .

ALZHEIMERS RESEARCH & THERAPY, 2012, 4 (03)

[8] Inflammatory proteins in plasma and the risk of dementia - The Rotterdam study [J].

Engelhart, MJ ;

Geerlings, MI ;

Meijer, J ;

Kiliaan, A ;

Ruitenberg, A ;

van Swieten, JC ;

Stijnen, T ;

Hofman, A ;

Witteman, JCM ;

Breteler, MMB .

ARCHIVES OF NEUROLOGY, 2004, 61 (05) :668-672

[9] Associations of Gene Sequence Variation and Serum Levels of C-Reactive Protein and Interleukin-6 with Alzheimer's Disease and Dementia [J].

Eriksson, Ulrika K. ;

Pedersen, Nancy L. ;

Reynolds, Chandra A. ;

Hong, Mun-Gwan ;

Prince, Jonathan A. ;

Gatz, Margaret ;

Dickman, Paul W. ;

Bennet, Anna M. .

JOURNAL OF ALZHEIMERS DISEASE, 2011, 23 (02) :361-369

[10]

Franceschi C, 2000, ANN NY ACAD SCI, V908, P244

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