Thyroid Disruption by Low-Dose BDE-47 in Prenatally Exposed Lambs

被引：41

作者：

Abdelouahab, Nadia ^{[1
]}

Suvorov, Alexander ^{[1
]}

Pasquier, Jean-Charles ^{[1
]}

Langlois, Marie-France ^{[2
]}

Praud, Jean-Paul ^{[3
]}

Takser, Larissa ^{[1
]}

机构：

[1] Univ Sherbrooke, Fac Med, Dept Obstet & Gynecol, Sherbrooke, PQ J1H 5N4, Canada

[2] Univ Sherbrooke, Fac Med, Dept Med, Serv Endocrinol, Sherbrooke, PQ J1H 5N4, Canada

[3] Univ Sherbrooke, Fac Med, Dept Pediat, Sherbrooke, PQ J1H 5N4, Canada

来源：

NEONATOLOGY | 2009年 / 96卷 / 02期

关键词：

Polybrominated diphenyl ethers; Sheep; pregnancy; Thyroid hormones; 2,2 ',4,4 '-Tetrabromodiphenyl ether (BDE-47); POLYBROMINATED DIPHENYL ETHERS; POLYCHLORINATED-BIPHENYLS PCBS; DEVELOPMENTAL EXPOSURE; DIETARY-INTAKE; HOUSE-DUST; SHORT-TERM; PBDES; HORMONE; TOXICOKINETICS; EXPRESSION;

D O I：

10.1159/000209316

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

The purpose of this study was to evaluate whether polybrominated diphenyl ethers (PBDE) at levels reported for human populations affect the thyroid state in pregnant sheep and lambs. Pregnant sheep were exposed to vehicle or BDE-47 (0.2, 2 and 20 mu g/kg b.w.) from the 5th to 15th week of gestation by intravenous injections weekly. Thyroid hormone levels and BDE-47 content in the blood of sheep and lambs and adipose tissue were analyzed. We observed a significant decrease in total T-4 and T-3 in exposed lambs without any effect in pregnant sheep. Our finding indicates that prenatal low-dose PBDE exposure results in PBDE storage in fat of offspring and can affect thyroid metabolism in the developing fetus. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：120 / 124

页数：5

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