Reconstruction of human hard-palate mucosal epithelium on de-epidermized dermis

被引：21

作者：

Cho, KH

Ahn, HT

Park, KC

Chung, JH

Kim, SW

Sung, MW

Kim, KH

Chung, PH

Eun, HC

Youn, JI

机构：

[1] Seoul Natl Univ Hosp, Coll Med, Dept Dermatol, Chongno Gu, Seoul 110744, South Korea

[2] Seoul Natl Univ Hosp, Coll Med, Dept Plast & Reconstruct Surg, Chongno Gu, Seoul 110744, South Korea

[3] Seoul Natl Univ Hosp, Coll Med, Dept Otolaryngol, Chongno Gu, Seoul 110744, South Korea

[4] Seoul Natl Univ Hosp, Coll Dent, Dept Oral Surg, Chongno Gu, Seoul 110744, South Korea

[5] Seoul Natl Univ Hosp, Lab Artificial Organ & Biomat, Clin Res Inst, Chongno Gu, Seoul 110744, South Korea

来源：

JOURNAL OF DERMATOLOGICAL SCIENCE | 2000年 / 22卷 / 02期

关键词：

hard-palate; de-epidermized dermis; three-dimensional culture;

D O I：

10.1016/S0923-1811(99)00056-0

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Artificial hard-palate mucosa equivalents were reconstructed using keratinocytes derived from normal human hard-palate and de-epidermized dermis. Reconstructed hard-palate mucosal epithelium formed in three-dimensional culture was compared to native hard-palate mucosal epithelium and reconstructed oral buccal mucosal epithelium with regard to keratin expression. Artificial hard-palate mucosal epithelium reconstructed in medium with delipidized serum showed a differentiation pattern similar to that of hard-palate epithelium in vivo. The present study also confirmed that keratinocytes derived from hard-palate mucosa are intrinsically different from those of nonkeratinizing oral surfaces. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：117 / 124

页数：8

共 19 条

[1] RETINOIC ACID IMPROVES EPIDERMAL MORPHOGENESIS [J].