Synthesis of new coumarin 3-(N-aryl) sulfonamides and their anticancer activity

被引：196

作者：

Reddy, NS ^{[1
]}

Mallireddigari, MR ^{[1
]}

Cosenza, S ^{[1
]}

Gumireddy, K ^{[1
]}

Bell, SC ^{[1
]}

Reddy, EP ^{[1
]}

Reddy, MVR ^{[1
]}

机构：

[1] Temple Univ, Sch Med, Fels Inst Canc Res, Philadelphia, PA 19140 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 15期

关键词：

coumarins; sulfonamides; Jun kinase;

D O I：

10.1016/j.bmcl.2004.05.016

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Synthesis of coumarin 3-(N-aryl) sulfonamides was accomplished either by Knoevenagel condensation of anilmosulfonylacetic acids with suitable salicylaidehydes or by the reaction of methyl anilmosulfonylacetates with substituted salicylaldehydes in presence of a catalytic amount of a base. All the compounds tested for antiproliferative activity in different cancer cell lines have shown GI(50) values less than 100 muM. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4093 / 4097

页数：5

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