Role of interleukin-6 in mediating mesangial cell proliferation and matrix production in vivo

被引:50
作者
Eitner, F
Westerhuis, R
Burg, M
Weinhold, B
Grone, HJ
Ostendorf, T
Ruther, U
Koch, KM
Rees, AJ
Floege, J
机构
[1] HANNOVER MED SCH,DIV NEPHROL 6840,D-30623 HANNOVER,GERMANY
[2] HANNOVER MED SCH,INST MOL BIOL,D-30623 HANNOVER,GERMANY
[3] UNIV MARBURG,DEPT PATHOL,MARBURG,GERMANY
[4] UNIV ABERDEEN,DEPT MED & THERAPEUT,ABERDEEN,SCOTLAND
基金
英国医学研究理事会;
关键词
D O I
10.1038/ki.1997.9
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Mesangial cell proliferation and matrix overproduction characterize many progressive glomerular diseases. Based on currently available data, the role of interleukin-6 (IL-6) in mediating mesangial cell proliferation and matrix production is controversial. The present study attempts to clarify this issue by showing that: (1) IL-6 knock out mice develop a normal glomerular architecture and in particular a normal mesangium (2) Mesangioproliferative glomerulonephritis induced by Habu snake venom is equally severe in IL-6 knock out mice as in control mice. (3) A continuous seven-day intraperitoneal infusion of 50 mu g recombinant human IL-6 into rats with a prior minimal (subnephrito-genic) injury to mesangial cells does not induce glomerular cell activation, cell proliferation, matrix production, leukocyte influx, platelet influx or proteinuria. (4) A continuous seven-day IL-6 infusion into rats with mesangioproliferative nephritis (anti-Thy 1.1 nephritis) increases matrix protein transcription in the absence of detectable effects on matrix protein accumulation and otherwise has no effect on the natural course of the disease. We conclude from these findings that IL-6 is not an important mediator of mesangial cell proliferation and matrix overproduction in vivo, and that currently little rationale exists to advocate anti-IL-6 therapy in mesangioproliferative disease states.
引用
收藏
页码:69 / 78
页数:10
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