Regulation of endothelial cell apoptosis in atherothrombosis

被引：84

作者：

Dimmeler, S ^{[1
]}

Haendeler, J ^{[1
]}

Zeiher, AM ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Dept Internal Med 4, D-60590 Frankfurt, Germany

来源：

CURRENT OPINION IN LIPIDOLOGY | 2002年 / 13卷 / 05期

关键词：

D O I：

10.1097/00041433-200210000-00009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Increasing evidence suggests that endothelial cell apoptosis might contribute to atherogenesis, plaque erosion and acute coronary syndromes. The present review article summarizes the current findings and discusses the potential role of endothelial cell apoptosis for coronary artery disease progression. Moreover, the signalling events that critically regulate endothelial cell apoptosis are discussed. The article focuses on the regulation of endothelial cell apoptosis by the redox balance, which is mainly determined by reactive oxygen species and nitric oxide. Moreover, the role of S-nitrosylation of protein targets for protection of endothelial cell apoptosis will be discussed.

引用

页码：531 / 536

页数：6

共 57 条

[1] Peripheral vascular endothelial dysfunction and apoptosis in old monkeys [J].

Asai, K ;

Kudej, RK ;

Shen, YT ;

Yang, GP ;

Takagi, G ;

Kudej, AB ;

Geng, YJ ;

Sato, N ;

Nazareno, JB ;

Vatner, DE ;

Natividad, F ;

Bishop, SP ;

Vatner, SF .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (06) :1493-1499

[2] Endothelial cells undergoing apoptosis become proadhesive for nonactivated platelets [J].

Bombeli, T ;

Schwartz, BR ;

Harlan, JM .

BLOOD, 1999, 93 (11) :3831-3838

[3] Apoptotic vascular endothelial cells become procoagulant [J].

Bombeli, T ;

Karsan, A ;

Tait, JF ;

Harlan, JM .

BLOOD, 1997, 89 (07) :2429-2442

[4] Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction [J].

Boulanger, CM ;

Scoazec, A ;

Ebrahimian, T ;

Henry, P ;

Mathieu, E ;

Tedgui, A ;

Mallat, Z .

CIRCULATION, 2001, 104 (22) :2649-2652

[5] THE ENDOTHELIUM OF ADVANCED ARTERIOSCLEROTIC PLAQUES IN HUMANS [J].

BURRIG, KF .

ARTERIOSCLEROSIS AND THROMBOSIS, 1991, 11 (06) :1678-1689

[6] Endothelial dysfunction in cardiovascular diseases - The role of oxidant stress [J].

Cai, H ;

Harrison, DG .

CIRCULATION RESEARCH, 2000, 87 (10) :840-844

[7] INCREASED ENDOTHELIAL CELL TURNOVER IN AREAS OF IN-VIVO EVANS-BLUE UPTAKE IN PIG AORTA [J].

CAPLAN, BA ;

SCHWARTZ, CJ .

ATHEROSCLEROSIS, 1973, 17 (03) :401-417

[8] Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis [J].

Carmeliet, P ;

Lampugnani, MG ;

Moons, L ;

Breviario, F ;

Compernolle, V ;

Bono, F ;

Balconi, G ;

Spagnuolo, R ;

Oosthuyse, B ;

Dewerchin, M ;

Zanetti, A ;

Angellilo, A ;

Mattot, V ;

Nuyens, D ;

Lutgens, E ;

Clotman, F ;

de Ruiter, MC ;

Gittenberger-de Groot, A ;

Poelmann, R ;

Lupu, F ;

Herbert, JM ;

Collen, D ;

Dejana, E .

CELL, 1999, 98 (02) :147-157

[9] Regulation of endothelial cell survival and apoptosis during angiogenesis [J].

Chavakis, E ;

Dimmeler, S .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (06) :887-893

[10] Nitric oxide inhibits tumor necrosis factor-α-induced apoptosis by reducing the generation of ceramide [J].

De Nadai, C ;

Sestili, P ;

Cantoni, O ;

Lièvremont, JP ;

Sciorati, C ;

Barsacchi, R ;

Moncada, S ;

Meldolesi, J ;

Clementi, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (10) :5480-5485

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