The emerging role of nuclear architecture in DNA repair and genome maintenance

被引：354

作者：

Misteli, Tom ^{[1
]}

Soutoglou, Evi ^{[2
]}

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

[2] Inst Genet & Biol Mol & Cellulaire, Dept Canc Biol, INSERM U 596, CNRS UMR 7104, Strasbourg, France

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 04期

基金：

美国国家卫生研究院;

关键词：

DOUBLE-STRAND BREAKS; HISTONE ACETYLTRANSFERASE HAT1P; DAMAGE RESPONSE; CELL-CYCLE; H2AX PHOSPHORYLATION; SPATIAL-ORGANIZATION; CHROMATIN-STRUCTURE; GENE-EXPRESSION; DISTINCT ROLES; CHECKPOINT;

D O I：

10.1038/nrm2651

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA repair and maintenance of genome stability are crucial to cellular and organismal function, and defects in these processes have been implicated in cancer and ageing. Detailed molecular, biochemical and genetic analyses have outlined the molecular framework involved in cellular DNA-repair pathways, but recent cell-biological approaches have revealed important roles for the spatial and temporal organization of the DNA-repair machinery during the recognition of DNA lesions and the assembly of repair complexes. It has also become clear that local higher-order chromatin structure, chromatin dynamics and non-random global genome organization are key factors in genome maintenance. These cell-biological features of DNA repair illustrate an emerging role for nuclear architecture in multiple aspects of genome maintenance.

引用

页码：243 / 254

页数：12

共 124 条

[1] H2B (Ser10) phosphorylation is induced during apoptosis and meiosis in S-cerevisiae [J].