Low levels of the vascular endothelial growth factor in CSF from early ALS patients

被引：93

作者：

Devos, D

Moreau, C

Lassalle, P

Perez, T

De Seze, J

Brunaud-Danel, V

Destée, A

Tonnel, AB

Just, N

机构：

[1] Ctr Hosp Reg & Univ Lille, Hop R Salengro, Dept Neurol, Neurol Clin, F-59037 Lille, France

[2] A Calmette Hosp, Dept Pneumol, Lille, France

[3] Univ Lille, Med Ctr, Multidisciplinary Ctr ALS, Pasteur Inst Lille,INSERM,U416, Lille, France

来源：

NEUROLOGY | 2004年 / 62卷 / 11期

关键词：

D O I：

10.1212/01.WNL.0000129913.44351.A3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Deletion of the hypoxia-response element in the vascular endothelial growth factor ( VEGF) promoter causes motor neuron degeneration in a mouse model. "At-risk" haplotypes with low circulating VEGF levels have been demonstrated in humans. Here the authors report low VEGF levels in the CSF of ALS patients during their first year of the disease, independently of VEGF promoter polymorphism. This finding early in ALS patients suggests a possible role for VEGF gene regulation in the pathogenesis of ALS.

引用

页码：2127 / 2129

页数：3

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