Hypnotic effects of total aqueous extracts of Vervain hastata (Verbenaceae) in rats

被引：14

作者：

Akanmu, MA ^{[1
]}

Honda, K ^{[1
]}

Inoué, S ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Dept Biocybernet, Chiyoda Ku, Tokyo 1010062, Japan

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 2002年 / 56卷 / 03期

关键词：

non-rapid eye movement sleep; rapid eye movement sleep; sedative; Vervain extract;

D O I：

10.1046/j.1440-1819.2002.01009.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The in vivo sedative property of the total aqueous extract of the aerial portion of Vervain hastata (Verbenaceae) (TAEV) was studied in male rats to establish its scientific basis in herbal medicine. The investigation was conducted using electroencephalogram (EEG) analysis, and the barbituric-hypnosis test. The results showed that TAEV potentiated the pentobarbital-induced hypnosis significantly by reducing sleep latency and increased sleeping time in a dose-dependent manner that was reversed by flumazenil. The EEG data demonstrated that extract administration augmented total sleep time, rapid eye movement (REM) sleep and non-REM sleep at the expense of wakefulness. The study's results clearly showed the scientific validity for the use of this plant as a sedative and possibly as a nerve tonic substance.

引用

页码：309 / 310

页数：2