Semi-synthetic analogs of pinitol as potential inhibitors of TNF-α cytokine expression in human neutrophils

被引：19

作者：

Bhat, Khurshid A. ^{[1
]}

Shah, Bhahwal A. ^{[1
]}

Gupta, Kuldeep K. ^{[1
]}

Pandey, Anjali ^{[1
]}

Bani, Sarang ^{[1
]}

Taneja, Subhash C. ^{[1
]}

机构：

[1] Indian Inst Integrat Med CSIR, Jammu 180001, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 07期

关键词：

Pinitol; Lipase; Acylates; Diacetonide; TNF-alpha expression; Flowcytometry; STREPTOZOTOCIN-DIABETIC RATS; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; (+)-PINITOL; MACROPHAGES; RECEPTORS; GLUCOSE;

D O I：

10.1016/j.bmcl.2009.02.050

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Semi-synthetic analogs of pinitol were subjected to screening by determining TNF-alpha expression in human neutrophils using flowcytometry. Among the tested compounds, three derivatives displayed more than 50% inhibition of TNF-alpha cytokine secretion in LPS induced stimulated neutrophils and can be considered as potent anti-inflammatory moieties. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1939 / 1943

页数：5

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