Sulfasalazine for alopecia areata

被引:27
作者
Ellis, CN [1 ]
Brown, ME
Voorhees, JJ
机构
[1] Univ Michigan, Sch Med, Dept Dermatol, A Alfred Taubman Ctr 1910, Ann Arbor, MI 48109 USA
[2] Dept Vet Affairs Ann Arbor Healthcare Syst, Dermatol Serv, Ann Arbor, MI USA
关键词
D O I
10.1067/mjd.2002.119671
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Sulfasalazine is used as a therapy for various autoimmune conditions, including psoriasis; its effectiveness is presumed to be the result of its immunomodulatory effects. We have treated patients with severe alopecia areata with sulfasalazine as part of our dermatology practice and have noticed cosmetically acceptable regrowth in 23% of patients in whom a response could be determined. In view of its good safety profile, sulfasalazine may be considered for systemic treatment of severe alopecia areata.
引用
收藏
页码:541 / 544
页数:4
相关论文
共 13 条
[1]  
BACHRACH WH, 1988, AM J GASTROENTEROL, V83, P487
[2]  
Box SA, 1997, BRIT J RHEUMATOL, V36, P382
[3]   CLINICAL PHARMACOKINETICS OF SULFASALAZINE [J].
DAS, KM ;
DUBIN, R .
CLINICAL PHARMACOKINETICS, 1976, 1 (06) :406-425
[4]   Alopecia areata in families: Association with the HLA locus [J].
de Andrade, M ;
Jackow, CM ;
Dahm, N ;
Hordinsky, M ;
Reveille, JD ;
Duvic, M .
JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, 1999, 4 (03) :220-223
[5]   Alopecia areata is a T-lymphocyte mediated autoimmune disease: Lesional human T-lymphocytes transfer alopecia areata to human skin grafts on SCID mice [J].
Gilhar, A ;
Shalaginov, R ;
Assy, B ;
Serafimovich, S ;
Kalish, RS .
JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, 1999, 4 (03) :207-210
[6]  
GUPTA AK, 1995, J RHEUMATOL, V22, P894
[7]   ORAL CYCLOSPORINE FOR THE TREATMENT OF ALOPECIA-AREATA - A CLINICAL AND IMMUNOHISTOCHEMICAL ANALYSIS [J].
GUPTA, AK ;
ELLIS, CN ;
COOPER, KD ;
NICKOLOFF, BJ ;
HO, VC ;
CHAN, LS ;
HAMILTON, TA ;
TELLNER, DC ;
GRIFFITHS, CEM ;
VOORHEES, JJ .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1990, 22 (02) :242-250
[8]   SULFASALAZINE IMPROVES PSORIASIS - A DOUBLE-BLIND ANALYSIS [J].
GUPTA, AK ;
ELLIS, CN ;
SIEGEL, MT ;
DUELL, EA ;
GRIFFITHS, CEM ;
HAMILTON, TA ;
NICKOLOFF, BJ ;
VOORHEES, JJ .
ARCHIVES OF DERMATOLOGY, 1990, 126 (04) :487-493
[9]   The potential role of cytokines and T cells in alopecia areata [J].
Hoffmann, R .
JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, 1999, 4 (03) :235-238
[10]   Alopecia areata investigational assessment guidelines [J].
Olsen, E ;
Hordinsky, M ;
McDonald-Hull, S ;
Price, V ;
Roberts, J ;
Shapiro, J ;
Stenn, K .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1999, 40 (02) :242-246