Vesicular transport across the fungal cell wall

被引：122

作者：

Casadevall, Arturo ^{[1
,2
,3
]}

Nosanchuk, Joshua D. ^{[1
,2
,3
]}

Williamson, Peter ^{[4
,5
]}

Rodrigues, Marcio L. ^{[6
]}

机构：

[1] Albert Einstein Coll Med, Dept Microbiol, Dept Med, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Immunol, Dept Med, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Dept Med, Div Infect Dis, Bronx, NY 10461 USA

[4] Univ Illinois, Dept Med, Div Infect Dis, Chicago, IL 60612 USA

[5] Jesse Brown VA Med Ctr, Chicago, IL 60612 USA

[6] Univ Fed Rio de Janeiro, Lab Estudos Integrados Bioquim Microbiana, Inst Microbiol Prof Paulo Goes, BR-21941590 Rio De Janeiro, Brazil

来源：

TRENDS IN MICROBIOLOGY | 2009年 / 17卷 / 04期

关键词：

CRYPTOCOCCUS-NEOFORMANS; SACCHAROMYCES-CEREVISIAE; MONOCLONAL-ANTIBODIES; MELANIN; YEAST; GLUCURONOXYLOMANNAN; POLYSACCHARIDE; DEGRADATION; INFECTION; VIRULENCE;

D O I：

10.1016/j.tim.2008.12.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent findings indicate that fungi use vesicular transport to deliver substances across their cell walls. Fungal vesicles are similar to mammalian exosomes and could originate from cytoplasmic multivesicular bodies. Vesicular transport enables the export of large molecules across the cell wall, and vesicles contain lipids, proteins and polysaccharides, many of which are associated with virulence. Concentration of fungal products in vesicles could increase their efficiency in food acquisition and/or delivering potentially noxious substances to other cells, such as amoebae or phagocytes. The discovery of vesicular transport in fungi opens many new avenues for investigation in basic cell biology and pathogenesis.

引用

页码：158 / 162

页数：5

共 33 条

[1] Vesicular transport in Histoplasma capsulatum:: an effective mechanism for trans-cell wall transfer of proteins and lipids in ascomycetes [J].

Albuquerque, Priscila Costa ;

Nakayasu, Ernesto S. ;

Rodrigues, Marcio L. ;

Frases, Susana ;

Casadevall, Arturo ;

Zancope-Oliveira, Rosely M. ;

Almeida, Igor C. ;

Nosanchuk, Joshua D. .

CELLULAR MICROBIOLOGY, 2008, 10 (08) :1695-1710

[2] Melanin from Fonsecaea pedrosoi induces production of human antifungal antibodies and enhances the antimicrobial efficacy of phagocytes [J].

Alviano, DS ;

Franzen, AJ ;

Travassos, LR ;

Holandino, C ;

Rozental, S ;

Ejzemberg, R ;

Alviano, CS ;

Rodrigues, ML .

INFECTION AND IMMUNITY, 2004, 72 (01) :229-237

[3] Cytokinesis in budding yeast: the relationship between actomyosin ring function and septum formation [J].

Bi, E .

CELL STRUCTURE AND FUNCTION, 2001, 26 (06) :529-537

[4]

CABIB E, 1987, ADV ENZYMOL RAMB, V59, P59

[5] 'Ready made' virulence and 'dual use' virulence factors in pathogenic environmental fungi -: the Cryptococcus neoformans paradigm [J].

Casadevall, A ;

Steenbergen, JN ;

Nosanchuk, JD .

CURRENT OPINION IN MICROBIOLOGY, 2003, 6 (04) :332-337

[6] PYRANOSE OXIDASE, A MAJOR SOURCE OF H2O2 DURING WOOD DEGRADATION BY PHANEROCHAETE-CHRYSOSPORIUM, TRAMETES-VERSICOLOR, AND OUDEMANSIELLA-MUCIDA [J].

DANIEL, G ;

VOLC, J ;

KUBATOVA, E .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1994, 60 (07) :2524-2532

[7] PASSAGE OF MOLECULES THROUGH YEAST-CELL WALLS - A BRIEF ESSAY-REVIEW [J].

DENOBEL, JG ;

BARNETT, JA .

YEAST, 1991, 7 (04) :313-323

[8] Microstructure of cell wall-associated melanin in the human pathogenic fungus cryptococcus neoformans [J].

Eisenman, HC ;

Nosanchuk, JD ;

Webber, JBW ;

Emerson, RJ ;

Camesano, TA ;

Casadevall, A .

BIOCHEMISTRY, 2005, 44 (10) :3683-3693

[9] Association of a myosin immunoanalogue with cell envelopes of Aspergillus fumigatus conidia and its participation in swelling and germination [J].

Esnault, K ;

El Moudni, B ;

Bouchara, JP ;

Chabasse, D ;

Tronchin, G .

INFECTION AND IMMUNITY, 1999, 67 (03) :1238-1244

[10] Dynamic changes in the morphology of Cryptococcus neoformans during murine pulmonary infection [J].

Feldmesser, M ;

Kress, Y ;

Casadevall, A .

MICROBIOLOGY-SGM, 2001, 147 :2355-2365

← 1 2 3 4 →