In vitro interactions between piperaquine, dihydroartemisinin, and other conventional and novel antimalarial drugs

被引：19

作者：

Davis, Timothy M. E.

Hamzah, Juliana

Ilett, Kenneth F.

Karunajeewa, Harin A.

Reeder, John C.

Batty, Kevin T.

Hackett, Sara

Barrett, P. Hugh R.

机构：

[1] Univ Western Australia, Sch Med & Pharmacol, Crawley, WA, Australia

[2] Papua New Guinea Inst Med Res, Goroka, Papua N Guinea

[3] Curtin Univ, Sch Pharm, Bentley, WA, Australia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 08期

关键词：

D O I：

10.1128/AAC.00177-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interactions between 4-aminoquinolines and related drugs were also indifferent/antagonistic. The clinical significance of mildly antagonistic DHA combinations is uncertain but may become important if parasite drug sensitivity declines.

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收藏

页码：2883 / 2885

页数：3

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