Effects of long-term consumption of a fermented infant formula (with Bifidobacterium breve c50 and Streptococcus thermophilus 065) on acute diarrhea in healthy infants

被引:134
作者
Thibault, H
Aubert-Jacquin, C
Goulet, O
机构
[1] Hop Necker Enfants Malad, F-75015 Paris, France
[2] Bledina SA, F-69654 Villefranche Sur Mer, France
关键词
Bifidobacteria; diarrhea; fermented milk; immunomodulation; infant;
D O I
10.1097/00005176-200408000-00004
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objective: To determine whether long-term consumption of a fermented infant formula could influence the incidence of acute diarrhea and its severity in healthy infants. Method: Nine hundred seventy-one infants, ranging in age from 4 to 6 months, were included in a randomized, double-blind, placebo-controlled trial during a period of 5 months. They consumed daily either a fermented infant formula (FF) (fermentation with Bifidobacterium breve C50 and Streptococcus thermophilus 065) or a standard infant formula (SF) of the same nutritional composition. Evaluation Criteria: Number and duration of acute diarrhea episodes were evaluated. Severity of the episodes was determined by the number of hospital admissions, incidence of dehydration, number of medical consultations, number of oral rehydration solution prescriptions, and number of formula switches. Results: Growth of the infants and acceptability of the formulas were identical in the two groups. Incidence, duration of diarrhea episodes, and number of hospital admissions did not differ significantly between groups. Episodes were less severe in the FF (fermented formula) group. There were fewer cases of dehydration 2.5% versus 6.1% (P = 0.01), fewer medical consultations (46% v 56.6%, P = 0.003), fewer ORS prescriptions 41.9% v 51.9% (P = 0.003) and fewer switches to other formulas (59.5% v 74.9%, P = 0.0001) in FF infants compared to SF. Conclusion: A fermented formula may reduce the severity of acute diarrhea among healthy young infants. This outcome may be linked to the bifidogenic effects of fermentation products and their interactions with the intestinal immune system. (C) 2004 Lippincott Williams Wilkins.
引用
收藏
页码:147 / 152
页数:6
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