Antiangiogenic therapy in human gastrointestinal malignancies

被引：8

作者：

Heidemann, J.

Binion, D. G.

Domschke, W.

Kucharzik, T.

机构：

[1] Univ Munster, Dept Med B, D-48129 Munster, Germany

[2] Med Coll Wisconsin, Dept Internal Med, Div Gastroenterol Hepatol, Milwaukee, WI 53226 USA

来源：

GUT | 2006年 / 55卷 / 10期

关键词：

D O I：

10.1136/gut.2005.088229

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Angiogenesis is a crucial process involved in numerous physiological and pathophysiological settings. During the past three decades, the field of tumour associated angiogenesis has been the focus of a plethora of basic research projects and clinical studies. Tumour associated neovessels satisfying the increased demand of oxygen and nutrients in malignant tumours are now emerging as specific targets for novel antineoplastic agents. This article discusses the present data on antiangiogenic treatment of human gastrointestinal malignancies, including gastric, pancreatic, and colorectal adenocarcinoma, and outlines potential future perspectives, such as development of surrogate markers of angiogenesis.

引用

页码：1497 / 1511

页数：15

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