Relation between thallium-201/iodine 123-BMIPP subtraction and fluorine 18 deoxyglucose polar maps in patients with hypertrophic cardiomyopathy

被引：4

作者：

Ito, Y ^{[1
]}

Hasegawa, S ^{[1
]}

Yamaguchi, H ^{[1
]}

Yoshioka, J ^{[1
]}

Uehara, T ^{[1
]}

Nishimura, T ^{[1
]}

机构：

[1] Osaka Univ, Div Tracer Kinet, Biomed Res Ctr D9, Sch Med, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF NUCLEAR CARDIOLOGY | 2000年 / 7卷 / 01期

关键词：

Tl-201/BMIPP subtraction polar map; FDG polar map; hypertrophic cardiomyopathy;

D O I：

10.1067/mnc.2000.99188

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Background. Clinical studies have shown discrepancies in the distribution of thallium-201 and iodine 123-beta-methyl-iodophenylpentadecanoic acid (BMIPP) in patients with hypertrophic cardiomyopathy (HCM). Myocardial uptake of fluorine 18 deoxyglucose (FDG) is increased in the hypertrophic area in HCM, Methods mid Results, We examined whether the distribution of a Tl-201/BMIPP subtraction polar map correlates with that of an FDG polar map. We normalized to maximum count each Tl-201 and BMIPP bull's-eye polar map of 6 volunteers and obtained a standard Tl-201/BMIPP subtraction polar map by subtracting a normalized BMIPP bull's-eye polar map from a normalized Tl-201 bull's-eye polar map. The Tl-201/BMIPP subtraction polar map was then applied to 8 patients with HCM (mean age 65 +/- 12 years) to evaluate the discrepancy between Tl-201 and BMIPP distribution. We compared the Tl-201/BMIPP subtraction polar map with an FDG polar map. In patients with HCM, the Tl-201/BMIPP subtraction polar map showed a focal uptake pattern in the hypertrophic area similar to that of the FDG polar map. By quantitative analysis, the severity score of the Tl-201/BMIPP subtraction polar map was significantly correlated with the percent dose uptake of the FDG polar map. Conclusion. These results suggest that this new quantitative method may be an alternative to FDG positron emission tomography for the routine evaluation of HCM.

引用

页码：16 / 22

页数：7

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