Cancer regression in patients after transfer of genetically engineered lymphocytes

被引：2010

作者：

Morgan, Richard A. ^{[1
]}

Dudley, Mark E. ^{[1
]}

Wunderlich, John R. ^{[1
]}

Hughes, Marybeth S. ^{[1
]}

Yang, James C. ^{[1
]}

Sherry, Richard M. ^{[1
]}

Royal, Richard E. ^{[1
]}

Topalian, Suzanne L. ^{[1
]}

Kammula, Udai S. ^{[1
]}

Restifo, Nicholas P. ^{[1
]}

Zheng, Zhili ^{[1
]}

Nahvi, Azam ^{[1
]}

de Vries, Christiaan R. ^{[1
]}

Rogers-Freezer, Linda J. ^{[1
]}

Mavroukakis, Sharon A. ^{[1
]}

Rosenberg, Steven A. ^{[1
]}

机构：

[1] NCI, Surg Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

SCIENCE | 2006年 / 314卷 / 5796期

关键词：

D O I：

10.1126/science.1129003

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Through the adoptive transfer of lymphocytes after host immunodepletion, it is possible to mediate objective cancer regression in human patients with metastatic melanoma. However, the generation of tumor-specific T cells in this mode of immunotherapy is often limiting. Here we report the ability to specifically confer tumor recognition by autologous lymphocytes from peripheral blood by using a retrovirus that encodes a T cell receptor. Adoptive transfer of these transduced cells in 15 patients resulted in durable engraftment at levels exceeding 10% of peripheral blood lymphocytes for at least 2 months after the infusion. We observed high sustained levels of circulating, engineered cells at 1 year after infusion in two patients who both demonstrated objective regression of metastatic melanoma lesions. This study suggests the therapeutic potential of genetically engineered cells for the biologic therapy of cancer.

引用

页码：126 / 129

页数：4

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