Adhesion to bone marrow stroma inhibits apoptosis of chronic lymphocytic leukemia cells

被引：58

作者：

Lagneaux, L ^{[1
]}

Delforge, A ^{[1
]}

De Bruyn, C ^{[1
]}

Bernier, M ^{[1
]}

Bron, D ^{[1
]}

机构：

[1] Inst Jules Bordet, Serv Med Interne, B-1000 Brussels, Belgium

来源：

LEUKEMIA & LYMPHOMA | 1999年 / 35卷 / 5-6期

关键词：

B-CLL; apoptosis; stromal cells; adhesion;

D O I：

10.1080/10428199909169609

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of monoclonal long-lived B cells which are apparently resistant to normal apoptotic regulation. Since bone marrow stromal cells play an essential role in B lymphopoiesis, we have investigated wether stromal cells influence B-CLL cell survival. Our results indicate that intimate contact with stromal cells reduces B-CLL cell apoptosis and prevents the loss of bcl-2 protein expression. Binding of B-CLL cells to stromal cells requires simultaneous action of beta 1 and beta 2 integrins. The interaction between B-CLL cells and other cell types seems important for their survival and may represent an important mechanism underlying accumulation of malignant cells in B-CLL patients.

引用

页码：445 / +

页数：11

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