Interleukin-18 and CD30 serum levels in patients with moderate-severe depression

被引：60

作者：

Merendino, RA

Di Rosa, AE

Di Pasquale, G

Minciullo, PL

Mangraviti, C

Costantino, A

Ruello, A

Gangemi, S ^{[1
]}

机构：

[1] Univ Messina, Sch Med, Univ Hosp G Martino, Sch Allergy & Clin Immunol, I-98125 Messina, Italy

[2] Univ Messina, Sch Med, Univ Hosp G Martino, Dept Human Pathol,Chair Immunopathol, I-98125 Messina, Italy

[3] Univ Messina, Sch Med, Univ Hosp G Martino, Dept Neurosci Psychiat & Anesthesiol,Chair Psychi, I-98125 Messina, Italy

[4] Univ Messina, Sch Med, Univ Hosp G Martino, Dept Med Interna, I-98125 Messina, Italy

来源：

MEDIATORS OF INFLAMMATION | 2002年 / 11卷 / 04期

关键词：

moderate-severe depression; IL-18; sCD30; serum;

D O I：

10.1080/096293502900000131

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interleukin-18 (IL-18), a pro-inflammatory cytokine that plays an important role in the T-cell-helper type 1 response, is a new member of the family of cytokines produced in the brain. CD30 is a marker of T-cell-helper type 2 lymphocytes. We evaluated IL-18 and CD30 serum levels in 10 patients affected by moderate-severe depression (MSD). We demonstrated for the first time that serum IL-18 levels of MSD patients were significantly higher than those of healthy donors. On the contrary, no significant difference was found between serum CD30 levels of MSD patients compared with those of healthy donors. These data strengthen the hypothesis that MSD disease is associated with an inflammatory response, mainly T-cell-helper type 1, and suggest an important role for IL-18 in the pathophysiology of MSD.

引用

页码：265 / 267

页数：3

共 5 条

[1] Cultures of astrocytes and microglia express interleukin 18 [J].