Genetic variability in response to infection: malaria and after

被引：55

作者：

Weatherall, D ^{[1
]}

Clegg, JB ^{[1
]}

机构：

[1] Univ Oxford, Westherall Inst Mol Med, John Radcliffe Hosp, Oxford OX3 9DS, England

来源：

GENES AND IMMUNITY | 2002年 / 3卷 / 06期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

malaria; thalassaemia; sickle cell anaemia; human evolution; host/pathogen interaction; murine malaria;

D O I：

10.1038/sj.gene.6363878

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent studies have shown that the relatively short period of exposure of human populations to malaria has left in its wake a wide range of genetic diversity. And there is growing evidence that other infectious agents have, or are, having the same effect. By integrating further studies of human populations with genetic analyses of susceptibility to murine malaria it should now be possible to determine some of the mechanisms involved in the variation of susceptibility to infectious disease, information which may have important practical implications for both the diagnosis and better management of these conditions.

引用

页码：331 / 337

页数：7

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