Diffusion of water in large demyelinating lesions: a follow-up study

被引：48

作者：

Castriota-Scanderbeg, A

Sabatini, U

Fasano, F

Floris, R

Fraracci, L

Di Mario, M

Nocentini, U

Caltagirone, C

机构：

[1] IRCCS, Santa Lucia Fdn, Dept Radiol, I-00179 Rome, Italy

[2] Univ Roma Tor Vergata, Dept Radiol, Rome, Italy

[3] Univ Roma Tor Vergata, IRCCS, Santa Lucia Fdn, Dept Neurol, I-00179 Rome, Italy

来源：

NEURORADIOLOGY | 2002年 / 44卷 / 09期

关键词：

multiple sclerosis; diffusion; magnetic resonance imaging;

D O I：

10.1007/s00234-002-0806-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied five patients with multiple sclerosis with one plaque of demyelination more than 2 cm in diameter, using conventional and diffusion-weighted MRI, soon after the onset of symptoms and over 1-36 months. The orientationally averaged diffusion coefficient < D > was increased in all the acute lesions, and increased further during follow-up in three. There was a strong correlation between < D > and the degree of low signal on T1-weighted images. The quantitative information provided by < D > allowed delineation of different diffusion patterns in large MS lesions, that may reflect heterogeneity of the anatomical substrate.

引用

页码：764 / 767

页数：4

共 12 条

[1]

BARKHOF F, 1995, INT MS J, V2, P4

[2]

Dagher AP, 1996, NEURORADIOLOGY, V38, P560

[3] Physiologic MRI of a tumefactive multiple sclerosis lesion [J].