Protective effect of a tuberculosis subunit vaccine based on a fusion of antigen 85B and ESAT-6 in the aerosol guinea pig model

被引：159

作者：

Olsen, AW

Williams, A

Okkels, LM

Hatch, G

Andersen, P

机构：

[1] Statens Serum Inst, Dept Infect Dis Immunol, DK-2300 Copenhagen S, Denmark

[2] Hlth Protect Agcy, Div Res, Salisbury, Wilts, England

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 10期

关键词：

D O I：

10.1128/IAI.72.10.6148-6150.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A fusion protein of antigen 85B (Ag85B) and ESAT-6 administered in cationic lipid vesicles conferred a highly significant level of protection against Mycobacterium tuberculosis in the guinea pig aerosol model of infection. The protection was manifested as delayed clinical illness and prolonged survival. Neither Ag85B nor ESAT-6 (independently or as a cocktail) induced significant protection in this model.

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页码：6148 / 6150

页数：3

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